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1. WO2020157762 - PRÉDICTION DE MÉTABOLITES SANGUINS


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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/IL2020/050121 80593
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
30 January 2020 31 January 2019
Applicant
YEDA RESEARCH AND DEVELOPMENT CO. LTD.
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
1. With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
a. forming part of the international application as filed:
in the form of an Annex C/ST.25 text file.
on paper or in the form of an image file.
b. furnished together with the international application under PCT Rule 13ter.1(a) for the purposes of international search only in the form of an Annex C/ST.25 text file.
c. furnished subsequent to the international filing date for the purposes of international search only:
in the form of an Annex C/ST.25 text file (Rule 13ter.1(a)).
on paper or in the form of an image file (Rule 13ter.1(b) and Administrative Instructions, Section 713).
2.
In addition, in the case that more than one version or copy of a sequence listing has been filed or furnished, the required statements that the information in the subsequent or additional copies is identical to that forming part of the application as filed or does not go beyond the application as filed, as appropriate, were furnished.
3.
Additional comments:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
This International Searching Authority found multiple inventions in this international application, as follows:
1. claims: 1-13, 25-31(completely); 24(partially)
Methods of predicting the quantity of a metabolite in the blood of a subject, comprising feeding a (selected) machine learning procedure with an amount of a plurality of microbes of a microbiome of the subject. Methods based thereon for diagnosing a disease. Methods based thereon for for altering the quantity/amount of said metabolite by administering an agent that increases/decreases the quantity/amount of at least one microbe, comprising feeding a machine learning procedure with an amount of a plurality of microbes of a microbiome of the subject, or a desired quantity of the metabolite.
2. claims: 14-23, 32-36(completely); 24(partially)
Methods of predicting the quantity of a metabolite in the blood of a subject, comprising feeding a (selected) machine learning procedure with a frequency of consumption of food types in a diet consumed by the subject. Methods based thereon for altering the quantity of said metabolite by administering an agent that alters the quantity of at least one microbe, or for providing dietary advice.
1.
As all required additional search fees were timely paid by the applicant, this international search report covers all searchable claims.
2.
As all searchable claims could be searched without effort justifying additional fees, this Authority did not invite payment of additional fees.
3.
As only some of the required additional search fees were timely paid by the applicant, this international search report covers only those claims for which fees were paid, specifically claims Nos.:
4.
No required additional search fees were timely paid by the applicant. Consequently, this international search report is restricted to the invention first mentioned in the claims; it is covered by claims Nos.: 1-13, 25-31(completely); 24(partially)
Remark on Protest
The additional search fees were accompanied by the applicant’s protest and, where applicable, the payment of a protest fee.
The additional search fees were accompanied by the applicant’s protest but the applicable protest fee was not paid within the time limit specified in the invitation.
No protest accompanied the payment of additional search fees.
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No.     11    
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     G16B 10/00 (2019.01)i; G16B 30/10 (2019.01)i; G16B 40/20 (2019.01)i; G16H 50/20 (2018.01)i; G16H 20/60 (2018.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     G16B; G16H
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, WPI Data

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
FERNÁNDEZ-NAVARRO T ET AL, "Exploring the interactions between serum free fatty acids and fecal microbiota in obesity through a machine learning algorithm", FOOD RESEARCH INTERNATIONAL,Vol. 121, 05 December 2018 (2018-12-05), page 533-541,
XP085687143
1-13,24-31
abstract
p.533 col.1-2, p.534 col.2 par.5-6, paragraph over pp.534-535, p.535 col.1 par.3-p.536 col.1 par.1, p.536 col.2, p.537 col.1 par.4-col.2 par.1;figure 1; tables 1, 4
(2)
X
LE CHATELIER E ET AL, "Richness of human gut microbiome correlates with metabolic markers", NATURE,Vol. 500, No. 7464, 28 August 2013 (2013-08-28), page 541-546,
XP055087499
1-7,11-13,24-31
abstract
title, p.543 col.2 par.4, p.544 col.1 par.2
(3)
X
ZEEVI D ET AL, "Personalized Nutrition by Prediction of Glycemic Responses", CELL, ELSEVIER, AMSTERDAM, NL,Vol. 163, No. 5, 19 November 2015 (2015-11-19), page 1079-1094,
XP029306473
1-5,8-12,27-30
abstract
p.1081 col.2 par.1, p.1084 col.2 par.3-5, p.1091 col.1 par.3, p.1091 col.2 par.6-p.1092 col.1 par.2;figure 2H
(4)
X
WO 2018129413 A1 (HENRY M JACKSON FOUND ADVANCEMENT MILITARY MEDICINE INC [US]) 12 July 2018 (2018-07-12)
28,29,31
A
[0006], [0012], [0015], [0026], [0124]-[0176], [0168], [0204]-[0221]
1-10,24-27
(5)
A
US 2018334704 A1 (LEONG PATRICK PAK TAK [US]) 22 November 2018 (2018-11-22)
1-13,24-31
[0040]-[0043], [0065]-[0067], [0083]-[0084], [0088]-[0091], [0108]-[0110];figures 1-2
(6)
A
WO 2018126033 A1 (ASCUS BIOSCIENCES INC [US]) 05 July 2018 (2018-07-05)
1-13,24-31
[0004]-[0005], [00218]-[00221];examples 3, 11
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"D"
document cited by the applicant in the international application
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
WO 2018129413 A1
12 July 2018
AU 2018206460 A1
CA 3049582 A1
EP 3566232 A1
JP 2020507746 A
US 2019354814 A1
WO 2018129413 A1
15 August 2019
12 July 2018
13 November 2019
12 March 2020
21 November 2019
12 July 2018
US 2018334704 A1
22 November 2018
US 2018334704 A1
WO 2018210338 A1
22 November 2018
22 November 2018
WO 2018126033 A1
05 July 2018
AU 2017388532 A1
CA 3048247 A1
CN 110392738 A
EP 3562956 A1
JP 2020507308 A
WO 2018126033 A1
25 July 2019
05 July 2018
29 October 2019
06 November 2019
12 March 2020
05 July 2018
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
23 April 2020
Date of mailing of the international search report:
09 July 2020
Authorized officer:
Werner, Andreas
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