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1. US20120282292 - Methods and compositions related to immunogenic fibrils

Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

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Claims

1. An immunogenic composition comprising a peptide fibril coupled to a plurality of antigens, wherein the peptide fibril comprises a plurality of self-assembling peptides, wherein the self-assembling peptide comprises an amino acid sequence of QQKFQFQFEQQ (SEQ ID NO: 1), and wherein an antigen is covalently coupled to a terminus of a self-assembling peptide.
2. The composition of claim 1, wherein the peptide fibril has a length of at least 0.5 to 100 μm.
3. The composition of claim 1, wherein the peptide fibril has a molecular weight of at least 10,000 da-7×10 8 da.
4. The composition of claim 1, wherein an antigen is covalently coupled to the carboxy terminus of the self-assembling peptide.
5. The composition of claim 1, wherein the antigens are peptides.
6. The composition of claim 5, wherein the antigens are T cell and/or B cell epitopes.
7. The composition of claim 1, wherein the antigens are polypeptides.
8. The composition of claim 7, wherein the polypeptides are covalently coupled to the peptide fibril via a cutinase polypeptide.
9. A method of inducing an immune response to an antigen comprising administering the immunogenic composition of claim 1 in an amount sufficient to induce an immune response.