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1. WO1984000549 - METHODE DE PREVENTION DE LA FIEVRE VITULAIRE CHEZ LE BETAIL A LAIT

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Claims

1. The method for treatment and prophylaxsis for milk fever disease in dairy cattle which comprises administering to said cattle prior to parturition a vitamin D derivative which is characterized by the presence of a hydroxyl
group at at least one of the C-1 and C-25 positions and a metabolically stable blocking group at the C-24
position in the molecule in an aroount sufficient to
induce said treatment and prophylaxsis.
2. The method of Cl aim 1 wherein the blocking group at the
C-24 position is selected from 24-monofluoro or 24- difluoro.
3. The methcd of Claims 1 or 2 wτierein the vitamin D
derivative is 25-hydroxylated.
4. The methcd of Claims 1 or 2 wherein the vitamin D
derivative is 1α-hydroxylated.
5. The method of Claims 1 or 2 wherein the vitamin D
derivative is 1α ,25-dilιydroxylated.
6. The method of Claim 3 wherein the vitamin D derivative is selected frαn 24 , 24-difluoro-25-hydroxyvitamin D3
and 24-fluoro-25-hydroxyvitamin D3 and 24-fluoro-1- hydroxyvitamin D2.
7. The method of Claim 6 wherein the vitamin D derivative is 24,24-difluoro-25-hydroxyvitamin D3.
8. The method of Claim 5 wherein the vitamin D derivative is selected from 24,24-di fluoro-1α,25-dihydroxyvitamin D3 and 24-fluoro-1α,25-dihydroxyvitamin D3.
9. The method of Claim 8 wherein the vitamin D derivative is 24 ,24-difluoro-1α,25-dihydroxyvitamin D3.
10. The method of Claim 1 wherein the vitamin D derivative is administered in an admixture of 24,24-difluoro-25- hydroxyvitamin D3 and 24 ,24-difluoro-1α,25-dihydroxy- vitamin D3.

11. The method of Claim 10 in which the 24,24-difluoro-25- hydroxyvitamin D3 and 24,24--difluoro-1α,25-dihydroxy
vitamin D3 are present respectively in the admixture
in a ratio of frαn about 5:1 to about 10:1.
12. The method of Claim 1 the vitamin D derivatives are
administered in an amount from about 0.1 to about 10 mg per animal frαn about 4 to 8 days prior to calving.
13. The method of Claim 12 wherein the vitamin D derivatives are administered by injection.
14. The method of Claim 13 wherein the injection is intramuscular.
15. The method of Claim 13 wherein the injection is subcutaneous.
16. The method of Claim 12 wherein the vitamin D derivatives are administered orally.
17. A composition for treating milk fever disease in dairy cattle which comprises at least one vitamin D derivative which is characterized by the presence of a hydroxyl group at at least one of the C-1 and C-25 positions in the molecule and a metabolically stable blocking group at the C-24 position and a veternarily acceptable excipient.
18. The composition of Claim 17 wherein the vitamin D derivative contains a blocking group at the C-24 position which is selected from 24-monofluoro or 24-difluoro.

19. The composition of Claim 18 wherein the vitamin D derivative is selected frαn 24,24-difluorc-25-hydroxy- vitamin D3, 24-fluoro-25-hydroxyvitamin D3 or 24-fluoro 1-hydroxyvitamin D3.
20. The composition of Claim 18 wherein the vitemin D derivative is 25-hydroxylated.
21. The composition of Claim 18 wherein the vitamin D derivative is 1α-hydroxylated.
22. The composition of Claim 17 wherein the vitamin D derivative is 1α,25-dihydroxylated.

23. The composition of Claim 22 wherein the vitamin D
derivative is selected from 24,24-difluoro-1α,25- dihydroxyvitemin D3 and 24-fluoro-1α,25-dihydroxy
vitamin D3.
24. The composition of Claim 17 co mprising an a dmixture of
24,24-difluoro-25-hydroxyvitamin D3 and 24,24-difluoro- 1α,25-dihydroxyvitamin D3.
25. The composition of Claim 24 in which the 24 ,24-difluoro- 25-hydroxyvitamin D3 and 24,24-difluoro-1α,25-dihydroxy vitamin D3 are present respectively in the admixture in a ratio of froma about 5:1 to about 10:1.
26. The composition of Claim 22 in the form of a bolus.
27. The composition of Claim 26 wherein the bolus contains at least 0.1 mg of the 1α,25-dihydroxylated vitamin D
derivative.
28. The composition of Claim 22 where the excipient is a
liquid and the composition is suitable for intramuscular injection.
29. The composition of Claim 22 where the excipient is an ingestible liquid and the composition is suitable for application to cattle feed as a top dressing.
30. The composition of Claim 29 where the liquid composition is absorbed, or adsorbed, on a solid ingestible
substrate, the then solid form of the composition being suitable for application to cattle feed as a top dressing.