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IC:A61M AND EN_ALLTXT:(coronavirus OR coronaviruses OR coronaviridae OR coronavirinae OR orthocoronavirus OR orthocoronaviruses OR orthocoronaviridae OR orthocoronavirinae OR betacoronavirus OR betacoronaviruses OR betacoronaviridae OR betacoronavirinae OR sarbecovirus OR sarbecoviruses OR sarbecoviridae OR sarbecovirinae OR "severe acute respiratory syndrome" OR sars OR "2019 ncov" OR covid)

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1 / 195
1.WO/2021/181261LACTOFERRIN FOR ORAL INHALATION USE FOR THE TREATMENT OF A DISEASE CAUSED BY A SARS-CORONA VIRUS
WO - 16.09.2021
Clasificación Internacional A61K 38/40
ANECESIDADES CORRIENTES DE LA VIDA
61CIENCIAS MEDICAS O VETERINARIAS; HIGIENE
KPREPARACIONES DE USO MEDICO, DENTAL O PARA EL ASEO
38Preparaciones medicinales que contienen péptidos
16Péptidos que tienen más de 20 aminoácidos; Gastrinas; Somatostatinas; Melanotropinas; Sus derivados
17que provienen de animales; que provienen de humanos
40Transferrinas, p. ej. lactoferrinas, ovotransferrinas
 Nº de solicitud PCT/IB2021/051941 Solicitante SOFAR S.P.A. Inventor/a BIFFI, Andrea
The present invention relates to a composition comprising lactoferrin for inhalation use in the treatment of viral infections of the respiratory system, and related symptoms or disorders, caused by a SARS- coronavirus (e.g. COVID-19 disease). In addition, the present invention relates to a device for the administration - through the inhalation route - of said composition comprising lactoferrin and the use thereof in said methods for the treatment of viral infections.
2.20210330663PRODUCTS OF MANUFACTURE AND METHODS FOR TREATING, PREVENTING, AMELIORATING OR PREVENTING CORONAVIRUS INFECTION
US - 28.10.2021
Clasificación Internacional A61K 31/4706
ANECESIDADES CORRIENTES DE LA VIDA
61CIENCIAS MEDICAS O VETERINARIAS; HIGIENE
KPREPARACIONES DE USO MEDICO, DENTAL O PARA EL ASEO
31Preparaciones medicinales que contienen ingredientes orgánicos activos
33Compuestos heterocíclicos
395que tienen el nitrógeno como heteroátomo de un ciclo, p. ej. guanetidina o rifamicina
435que tienen ciclos con seis eslabones con un nitrógeno como único heteroátomo de un ciclo
47Quinoleínas; Isoquinoleínas
47064-Aminoquinoleínas; 8-Aminoquinoleínas, p. ej. cloroquina, primaquina
 Nº de solicitud 17371009 Solicitante CENTRE FOR DIGESTIVE DISEASES Inventor/a Thomas Julius BORODY

In alternative embodiments, provided are pharmaceutical compositions comprising combinations of drugs, including products of manufacture and kits, and methods for using them, for treating, preventing, ameliorating, slowing the progress of, decreasing the severity of or preventing a coronavirus infection, or a COVID-19 or a 2019-nCoV (or so-called Wuhan coronavirus) infection, or an infection caused by a virus in the subfamily Orthocoronavirinae, or a virus in the family Coronaviridae, or a virus in the order Nidovirales. In alternative embodiments, combinations, or cocktails, of a drug or drugs as provided herein are administered either enterally, parenterally and/or by inhalation. In alternative embodiments, combinations, or cocktails, of drugs as provided herein are used to block intracellular metabolic pathways and prevent progression of the infection to clinical illness and death. In alternative embodiments, novel aerosol or powder formulations for inhalation are provided. In alternative embodiments, provided are therapeutic combinations of drugs or a drug, a pharmaceutical dosage form, a drug delivery device, or a product of manufacture, comprising: opaganib or YELIVA™, or opaganib or YELIVA™ and oral and/or inhaled chloroquine (or ARALEN™), chloroquine phosphate, chloroquine diphosphate and/or hydroxychloroquine (e.g., PLAQUENIL™), wherein optionally each or both of the opaganib and the chloroquine (or ARALEN™), chloroquine phosphate, chloroquine diphosphate and/or hydroxychloroquine (e.g., PLAQUENIL™) are in or formulated as a formulation for inhalation, for example, formulated as an aerosol, liquid or powder.

3.WO/2021/212183PRODUCTS OF MANUFACTURE AND METHODS FOR TREATING, AMELIORATING OR PREVENTING MICROBIAL INFECTIONS
WO - 28.10.2021
Clasificación Internacional A61K 31/4706
ANECESIDADES CORRIENTES DE LA VIDA
61CIENCIAS MEDICAS O VETERINARIAS; HIGIENE
KPREPARACIONES DE USO MEDICO, DENTAL O PARA EL ASEO
31Preparaciones medicinales que contienen ingredientes orgánicos activos
33Compuestos heterocíclicos
395que tienen el nitrógeno como heteroátomo de un ciclo, p. ej. guanetidina o rifamicina
435que tienen ciclos con seis eslabones con un nitrógeno como único heteroátomo de un ciclo
47Quinoleínas; Isoquinoleínas
47064-Aminoquinoleínas; 8-Aminoquinoleínas, p. ej. cloroquina, primaquina
 Nº de solicitud PCT/AU2021/050369 Solicitante TOPELIA AUST LIMITED Inventor/a BORODY, Thomas Julius
Provided are products of manufacture fabricated or manufactured as medical devices such as an inhaler, an ionizer, an asthma "puffer-like" device, a nebulizer or a nasal spray device, a respirator or a ventilator, a warm or a hot air delivery device, and/or a CPAP (continuous positive air pressure) device or equivalent, for delivering one or a combination of medications or drugs, and optionally also warm or hot air, and optionally also ionized air. Said drug combinations include various combinations of antivirals, antiparasitics, antibacterials, and adjunct therapeutics, including at least one of Hydroxychloroquine, Chloroquine, Oseltamivir, Lopinavir, Ritonavir, Ribavirin, Favipiravir, Remdesivir, Azithromycin, Ivermectin, Doxycycline, and Opaganib or combinations thereof. Products of manufacture are used for treating, preventing, ameliorating, slowing the progress of, decreasing the severity of or preventing a microbial infection, such as bacterial and viral infections, including the common respiratory viruses such as influenza vims, respiratory syncytial vims, picornavims, parainfluenza vims, adenovims, rhinovims, human metapneumovims, hantavimses, enterovims, a coronavims infection, or a COVID-19 or a 2019-nCoV (SARS-CoV-2) infection, or an infection caused by a vims in the subfamily Orthocoronavirinae, or a vims in the family Coronaviridae, or a vims in the order Nidovirales. In alternative embodiments, products of manufacture as provided herein administer combinations, or cocktails, of a dmg or dmgs by inhalation, for example, by use of aerosol, mist, liquid or powder formulations for inhalation.
4.20230081837PRODUCTS OF MANUFACTURE AND METHODS FOR TREATING, AMELIORATING OR PREVENTING CORONAVIRUS INFECTION
US - 16.03.2023
Clasificación Internacional A61K 31/4706
ANECESIDADES CORRIENTES DE LA VIDA
61CIENCIAS MEDICAS O VETERINARIAS; HIGIENE
KPREPARACIONES DE USO MEDICO, DENTAL O PARA EL ASEO
31Preparaciones medicinales que contienen ingredientes orgánicos activos
33Compuestos heterocíclicos
395que tienen el nitrógeno como heteroátomo de un ciclo, p. ej. guanetidina o rifamicina
435que tienen ciclos con seis eslabones con un nitrógeno como único heteroátomo de un ciclo
47Quinoleínas; Isoquinoleínas
47064-Aminoquinoleínas; 8-Aminoquinoleínas, p. ej. cloroquina, primaquina
 Nº de solicitud 17798044 Solicitante TOPELIA AUSTRALIA PTY LTD Inventor/a Thomas Julius BORODY

In alternative embodiments, provided are pharmaceutical compositions comprising combinations of drugs, including products of manufacture and kits, and methods for using them, for treating, preventing, ameliorating, slowing the progress of, decreasing the severity of or preventing a coronavirus infection, or a COVID-19 or a 2019-nCoV (or so-called Wuhan coronavirus) infection, or an infection caused by a virus in the subfamily Orthocoronavirinae, or a virus in the family Coronaviridae, or a virus in the order Nidovirales. In alternative embodiments, combinations, or cocktails, of a drug or drugs as provided herein are administered either enterally, parenterally and/or by inhalation. In alternative embodiments, combinations, or cocktails, of drugs as provided herein are used to block intracellular metabolic pathways and prevent progression of the infection to clinical illness and death. In alternative embodiments, novel aerosol, spray or mist or powder formulations for inhalation are provided. In alternative embodiments, provided are therapeutic combinations of drugs or a drug, a pharmaceutical dosage form, a drug delivery device, or a product of manufacture, comprising: opaganib or YELIVA™, or opaganib or YELIVA™ and oral and/or inhaled chloroquine (or ARALEN™) chloroquine phosphate, chloroquine diphosphate and/or hydroxychloroquine (optionally, PLAQUENIL™), with or without azithromycin, wherein optionally each or all of the opaganib, the chloroquine (or ARALEN™), chloroquine phosphate, chloroquine diphosphate and/or hydroxychloroquine (optionally, PLAQUENIL™), and/or azithromycin, and others, are in or formulated as a formulation for inhalation, for example, formulated as an aerosol, spray, mist, liquid or powder.

5.11052073Sphingosine kinase 2 inhibitor for treating coronavirus infection
US - 06.07.2021
Clasificación Internacional A61K 31/4409
ANECESIDADES CORRIENTES DE LA VIDA
61CIENCIAS MEDICAS O VETERINARIAS; HIGIENE
KPREPARACIONES DE USO MEDICO, DENTAL O PARA EL ASEO
31Preparaciones medicinales que contienen ingredientes orgánicos activos
33Compuestos heterocíclicos
395que tienen el nitrógeno como heteroátomo de un ciclo, p. ej. guanetidina o rifamicina
435que tienen ciclos con seis eslabones con un nitrógeno como único heteroátomo de un ciclo
44Piridinas no condensadas; Sus derivados hidrogenados
4409sustituidos unicamente en posición 4, p. ej. isoniazida, iproniazida
 Nº de solicitud 17195279 Solicitante RedHill Biopharma Ltd. Inventor/a Dror Ben-Asher

The disclosure is directed to ABC294640, as free base or as salts thereof, in preparing medicines for treating coronavirus infection or preventing diseases caused by coronavirus infection, and a medicine for preventing coronavirus infection or preventing diseases caused by coronavirus infection.

6.WO/2021/191886COMPOSITIONS COMPRISING TERPENES AND TERPENOIDS AND USE THEREOF FOR PREVENTING AND TREATING VIRAL-INDUCED INFECTIONS OF THE RESPIRATORY SYSTEM
WO - 30.09.2021
Clasificación Internacional A61K 36/00
ANECESIDADES CORRIENTES DE LA VIDA
61CIENCIAS MEDICAS O VETERINARIAS; HIGIENE
KPREPARACIONES DE USO MEDICO, DENTAL O PARA EL ASEO
36Preparaciones medicinales de constitución indeterminada que contienen sustancias procedentes de algas, líquenes, hongos o plantas o sus derivados, p. ej. medicinas tradicionales basadas en plantas
 Nº de solicitud PCT/IL2021/050218 Solicitante EYBNA TECHNOLOGIES LTD. Inventor/a EYAL, Nadav
Provided herein are compositions comprising a plurality of terpenes terpenoids and uses thereof for preventing viral induced severe acute respiratory syndrome (SARS), reducing the risk of infection and treating viral infections.
7.20220031682Sphingosine kinase 2 inhibitor for treating coronavirus infection
US - 03.02.2022
Clasificación Internacional A61K 31/4409
ANECESIDADES CORRIENTES DE LA VIDA
61CIENCIAS MEDICAS O VETERINARIAS; HIGIENE
KPREPARACIONES DE USO MEDICO, DENTAL O PARA EL ASEO
31Preparaciones medicinales que contienen ingredientes orgánicos activos
33Compuestos heterocíclicos
395que tienen el nitrógeno como heteroátomo de un ciclo, p. ej. guanetidina o rifamicina
435que tienen ciclos con seis eslabones con un nitrógeno como único heteroátomo de un ciclo
44Piridinas no condensadas; Sus derivados hidrogenados
4409sustituidos unicamente en posición 4, p. ej. isoniazida, iproniazida
 Nº de solicitud 17502932 Solicitante RedHill Biopharma Ltd. Inventor/a Dror Ben-Asher

The disclosure is directed to ABC294640, as free base or as salts thereof, in preparing medicines for treating coronavirus infection or preventing diseases caused by coronavirus infection, and a medicine for preventing coronavirus infection or preventing diseases caused by coronavirus infection.

8.WO/2021/204955COMPOUNDS FOR TREATING PNEUMONIA, SEPSIS, AND CORONAVIRUS INFECTION
WO - 14.10.2021
Clasificación Internacional A61K 31/46
ANECESIDADES CORRIENTES DE LA VIDA
61CIENCIAS MEDICAS O VETERINARIAS; HIGIENE
KPREPARACIONES DE USO MEDICO, DENTAL O PARA EL ASEO
31Preparaciones medicinales que contienen ingredientes orgánicos activos
33Compuestos heterocíclicos
395que tienen el nitrógeno como heteroátomo de un ciclo, p. ej. guanetidina o rifamicina
435que tienen ciclos con seis eslabones con un nitrógeno como único heteroátomo de un ciclo
46Aza-8-biciclooctano; Sus derivados, p. ej. atropina, cocaína
 Nº de solicitud PCT/EP2021/059201 Solicitante HEIDELBERG IMMUNOTHERAPEUTICS GMBH Inventor/a SCHALLER, Torsten
The present invention relates to an immune modulator comprising (i) a compound of formula I or a pharmaceutically acceptable salt or solvate thereof: wherein X and Y are independently selected from -CH2- and -O-, preferably are -CH2-; Z is N or C, preferably is N; m is an integer of from 0 to 3, preferably is 0; n is an integer of from 1 to 3, preferably is 1; R1 is, optionally substituted, C5-C6 cycloalkyl or aryl; R2 is, optionally substituted, aryl or heteroaryl; R3 and R4 are -H, or R3 and R4 together form a -CH2-CH2- bridge; R5 and R7 are independently selected from alkyl, preferably methyl and isopropyl; and in case Z is N, R6 is absent, or, in case Z is C, R6 together with R5 forms a -CH=CH-CH=CH- bridge; and/or (ii) a C-C chemokine receptor type 5 (CCR5) inhibitor, for use in treating and/or preventing pneumonia, sepsis, and/or coronavirus infection in a subject, and to methods, uses, kits an devices related thereto.
9.20220047686METHODS FOR TREATING INFECTIOUS DISEASES
US - 17.02.2022
Clasificación Internacional A61K 38/48
ANECESIDADES CORRIENTES DE LA VIDA
61CIENCIAS MEDICAS O VETERINARIAS; HIGIENE
KPREPARACIONES DE USO MEDICO, DENTAL O PARA EL ASEO
38Preparaciones medicinales que contienen péptidos
16Péptidos que tienen más de 20 aminoácidos; Gastrinas; Somatostatinas; Melanotropinas; Sus derivados
43Enzimas; Proenzimas; Sus derivados
46Hidrolasas (3)
48que actúan sobre enlaces peptídicos (3.4)
 Nº de solicitud 17384039 Solicitante Mayo Foundation for Medical Education and Research Inventor/a Samuel J. Asirvatham

Various methods and devices of treating infectious diseases are described. In one example embodiment, a method of treating an infectious disease in an individual in need thereof is provided, including administering a therapeutic agent to the individual and electroporating a tissue of the individual, wherein the therapeutic agent is inhalable.

10.WO/2021/243372CLOSED-LOOP ANTIMICROBIAL PHOTO-PLASMAPHERESIS
WO - 02.12.2021
Clasificación Internacional A61M 1/36
ANECESIDADES CORRIENTES DE LA VIDA
61CIENCIAS MEDICAS O VETERINARIAS; HIGIENE
MDISPOSITIVOS PARA INTRODUCIR AGENTES EN EL CUERPO O PARA DEPOSITARLOS SOBRE EL MISMO; DISPOSITIVOS PARA HACER CIRCULAR LOS AGENTES POR EL CUERPO O PARA SU EXTRACCION; DISPOSITIVOS PARA INDUCIR UN ESTADO DE SUEÑO O LETARGIA O PARA PONERLE FIN
1Dispositivos de succión o de bombeo de uso médico; Dispositivos para extraer, tratar o transportar los líquidos del cuerpo; Sistemas de drenaje
36Otros tratamientos de la sangre en una derivación del sistema circulatorio natural, p. ej. adaptación de la temperatura, irradiación
 Nº de solicitud PCT/US2021/070633 Solicitante BAYLOR COLLEGE OF MEDICINE Inventor/a SZIGETI, Reka
The present disclosure concerns systems and methods related to the treatment, prevention, delay of onset, or reduction of severity of a microbial infection in an individual, including closed-loop plasmapheresis and extracorporeal light irradiation of the plasma of the individual. The systems and methods further relate to irradiation of the plasma of the individual with UV and/or visible light, optionally in the presence of a photosensitizer. The systems and methods further relate to light irradiation inactivation of microbial particles in the plasma taken from the individual. The systems and methods further relate to the optional filtration of microbial particles from UV light-treated plasma. The systems and methods further relate to reinfusion of the UV light-treated, optionally filtered, plasma back into the individual. The systems and methods further relate to treating, preventing, delaying onset of, or reducing in severity a viral infection, particularly a viral infection caused by a Coronaviridae family virus, at least including SARS-CoV-2. The systems and methods are further configured to reduce viral load and/or lymphocyte reinfection rate in the individual.
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