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1. (WO2019064245) A COMPOSITION FOR USE IN THE PREVENTION AND/OR TREATMENT OF GLAUCOMA
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CLAIMS

1 . A composition comprising as the active ingredients a Crocus sativus extract and forskolin, characterised in that it comprises citicoline and/or rutin as further active ingredients.

2. The composition according to claim 1 , comprising roots of a plant of the genus Coleus as the forskolin source.

3. The composition according to claim 1 or 2, comprising bark of a plant of the genus Cotinus as the rutin source.

4. The composition according to any one of claims 1 to 3, wherein the Crocus sativus extract is present in the composition in an amount comprised within the range of from 0.1% to 40% by weight based on the total weight of the composition, preferably in an amount comprised within the range of from 0.5% to 30% by weight based on the total weight of the composition.

5. The composition according to any one of claims 1 to 4, wherein forskolin is present in the composition in an amount comprised within the range of from 1% to 70% by weight based on the total weight of the composition, preferably in an amount comprised within the range of from 5% to 50% by weight based on the total weight of the composition.

6. The composition according to any one of claims 1 to 5, wherein rutin is present in the composition in an amount comprised within the range of from 5% to 80% by weight based on the total weight of the composition, preferably in an amount comprised within the range of from 10% to 60% by weight based on the total weight of the composition.

7. The composition according to any one of claims 1 to 6, wherein citicoline is present in the composition in an amount comprised within the range of from 1% to 90% by weight based on the total weight of the composition, preferably in an amount comprised within the range of from 5% to 80% by weight based on the total weight of the composition.

8. The composition according to any one of claims 1 to 7, wherein said composition is a dietary supplement, a nutraceutical composition, a dietetic composition, a nutritional composition, a food product, a beverage, a food for special medical purposes, a medicated food, a pharmaceutical composition, a medical device or a cosmetic composition.

9. The composition according to claim 8, which is formulated as an oral dosage form or a topical dosage form.

10. The composition according to any one of claims 1 to 9, for use in the prevention and/or treatment of glaucoma.