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1. (WO2019043059) COMPOSITIONS AND METHODS FOR TREATING CANCER WITH ANTI-EGFR ANTIBODIES



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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/EP2018/073243 SPG19726PCT
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
29 August 2018 30 August 2017
Applicant
SYMPHOGEN A/S
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
1. With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
a. forming part of the international application as filed:
in the form of an Annex C/ST.25 text file.
on paper or in the form of an image file.
b. furnished together with the international application under PCT Rule 13ter.1(a) for the purposes of international search only in the form of an Annex C/ST.25 text file.
c. furnished subsequent to the international filing date for the purposes of international search only:
in the form of an Annex C/ST.25 text file (Rule 13ter.1(a)).
on paper or in the form of an image file (Rule 13ter.1(b) and Administrative Instructions, Section 713).
2.
In addition, in the case that more than one version or copy of a sequence listing has been filed or furnished, the required statements that the information in the subsequent or additional copies is identical to that forming part of the application as filed or does not go beyond the application as filed, as appropriate, were furnished.
3.
Additional comments:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
COMPOSITIONS AND METHODS FOR TREATING CANCER WITH ANTI-EGFR ANTIBODIES

5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     C12Q 1/6886 (2018.01)i; C07K 16/28 (2006.01)i; C07K 16/30 (2006.01)i; A61P 35/00 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     C12Q; C07K
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, BIOSIS, EMBASE, WPI Data

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
WO 2016172584 A1 (MERRIMACK PHARMACEUTICALS INC [US]; ARENA SABRINA [IT]) 27 October 2016 (2016-10-27)
1-52
page 1, line 21 - page 2, line 12
page 2, lines 19-23
page 20, lines 7-11
claim 7
examples 3,4,5-9,11,12,15
(2)
X
WO 2010022736 A2 (SYMPHOGEN AS [DK]; PEDERSEN MIKKEL WANDAHL [DK]; KRAGH MICHAEL [DK]; H) 04 March 2010 (2010-03-04)
42-46,50,51
100% identity with seq.1-4;claim 1; sequences 72,73
examples 21-25
(3)
X
F. J. SANCHEZ-MARTIN ET AL, "The First-in-class Anti-EGFR Antibody Mixture Sym004 Overcomes Cetuximab Resistance Mediated by EGFR Extracellular Domain Mutations in Colorectal Cancer", CLINICAL CANCER RESEARCH,Vol. 22, No. 13, 17 February 2016 (2016-02-17), page 3260-3267,
XP055517918
1-52
the whole document
(4)
A
WO 2010028288 A2 (AUEON INC [US]; STEPHAN DIETRICH [US]; NORVIEL VERN [US]; WARRINGTON J) 11 March 2010 (2010-03-11)
1-52
claims 1,34-40
paragraphs [0163], [0164]
(5)
A
EP 2977464 A1 (TOPPAN PRINTING CO LTD [JP]) 27 January 2016 (2016-01-27)
1-52
claims
(6)
A
WO 2016112064 A2 (UNIV JOHNS HOPKINS [US]; DEPT OF ONCOLOGY CANDIOLO BRANCH UNIVERSITY O) 14 July 2016 (2016-07-14)
1-52
paragraph [0003]
pages -; claims
(7)
A,P
JOHN H. STRICKLER ET AL, "Genomic Landscape of Cell-Free DNA in Patients with Colorectal Cancer", CANCER DISCOVERY,Vol. 8, No. 2, 01 December 2017 (2017-12-01), page 164-173,
XP055518243
1-52
the whole document
(8)
X,P
CLARA MONTAGUT ET AL, "Efficacy of Sym004 in Patients With Metastatic Colorectal Cancer With Acquired Resistance to Anti-EGFR Therapy and Molecularly Selected by Circulating Tumor DNA Analyses : A Phase 2 Randomized Clinical Trial", JAMA ONCOLOGY,Vol. 4, No. 4, 12 April 2018 (2018-04-12), page e175245,
XP055517926
1-52
the whole document
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
WO 2016172584 A1
27 October 2016
AU 2016252877 A1
CA 2983890 A1
CN 107889463 A
EP 3286219 A1
JP 2018516870 A
KR 20170138539 A
US 2016311908 A1
WO 2016172584 A1
09 November 2017
27 October 2016
06 April 2018
28 February 2018
28 June 2018
15 December 2017
27 October 2016
27 October 2016
WO 2010022736 A2
04 March 2010
AU 2009287163 A1
BR PI0918768 A2
CA 2732856 A1
CN 102137874 A
EP 2331577 A2
ES 2638579 T3
IL 210348 A
JP 5719298 B2
JP 2012500814 A
KR 20110050542 A
RU 2011111746 A
TW 201010726 A
US 2011229463 A1
WO 2010022736 A2
ZA 201100301 B
04 March 2010
01 December 2015
04 March 2010
27 July 2011
15 June 2011
23 October 2017
21 April 2016
13 May 2015
12 January 2012
13 May 2011
10 October 2012
16 March 2010
22 September 2011
04 March 2010
26 October 2011
WO 2010028288 A2
11 March 2010
EP 2318552 A2
EP 3216874 A1
GB 2467691 A
US 2011230360 A1
US 2014080733 A1
US 2014141426 A1
US 2014141980 A1
US 2016115553 A1
US 2016115554 A1
US 2016122830 A1
US 2016362749 A1
WO 2010028288 A2
11 May 2011
13 September 2017
11 August 2010
22 September 2011
20 March 2014
22 May 2014
22 May 2014
28 April 2016
28 April 2016
05 May 2016
15 December 2016
11 March 2010
EP 2977464 A1
27 January 2016
CN 105074009 A
EP 2977464 A1
JP WO2014148557 A1
SG 10201707548R A
SG 11201507739T A
US 2016002741 A1
WO 2014148557 A1
18 November 2015
27 January 2016
16 February 2017
30 October 2017
29 October 2015
07 January 2016
25 September 2014
WO 2016112064 A2
14 July 2016
US 2018346987 A1
WO 2016112064 A2
06 December 2018
14 July 2016
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
30 October 2018
Date of mailing of the international search report:
03 January 2019
Authorized officer:
Covone-van Hees, M
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