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1. (WO2018226685) METHODS FOR SENSITIZING CANCER CELLS TO T CELL-MEDIATED KILLING BY MODULATING MOLECULAR PATHWAYS
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公布号: WO/2018/226685 国际申请号: PCT/US2018/036046
公布日: 13.12.2018 国际申请日: 05.06.2018
国际专利分类:
A61K 38/46 (2006.01) ,A61K 48/00 (2006.01) ,A61P 35/00 (2006.01) ,C12N 15/113 (2010.01)
A 人类生活必需
61
医学或兽医学;卫生学
K
医用、牙科用或梳妆用的制剂
38
含肽的医药配制品
16
含有20个以上氨基酸的肽;胃泌激素;生长素抑制素;促黑激素;其衍生物
43
酶;酶原;其衍生物
46
水解酶(3)
A 人类生活必需
61
医学或兽医学;卫生学
K
医用、牙科用或梳妆用的制剂
48
含有插入到活体细胞中的遗传物质以治疗遗传病的医药配制品;基因治疗
A 人类生活必需
61
医学或兽医学;卫生学
P
化合物的治疗活性
35
抗肿瘤药
C 化学;冶金
12
包括微生物或酶的生物化学、微生物学、酶学,它们的制备;用其来合成化合物或组合物;涉及微生物或酶的测定或检验方法;变异或遗传工程
N
微生物或酶;其组合物;繁殖、保藏或维持微生物;变异或遗传工程;培养基
15
突变或遗传工程;遗传工程涉及的DNA或RNA,载体(如质粒)或其分离、制备或纯化;所使用的宿主
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
113
调节基因表达的非编码核酸,如反义寡核苷酸
申请人:
PAN, Deng; US
WUCHERPFENNIG, Kai, W.; US
DANA-FARBER CANCER INSTITUTE, INC. [US/US]; 450 Brookline Avenue Boston, MA 02215-5450, US
发明人:
PAN, Deng; US
WUCHERPFENNIG, Kai, W.; US
代理人:
SMITH, DeAnn, F.; US
BROW, William, E.; US
ABELLEIRA, Susan, M.; US
BLOUNT, Jennifer, V.; US
AKHIEZER, Alexander;; US
优先权数据:
62/515,73806.06.2017US
标题 (EN) METHODS FOR SENSITIZING CANCER CELLS TO T CELL-MEDIATED KILLING BY MODULATING MOLECULAR PATHWAYS
(FR) PROCÉDÉS DE SENSIBILISATION DE CELLULES CANCÉREUSES À UNE DESTRUCTION MÉDIÉE PAR DES LYMPHOCYTES T PAR MODULATION DE VOIES MOLÉCULAIRES
摘要:
(EN) The present invention is based, in part, on the identification of novel biomarkers, and methods of modulate thereof, for sensitizing cancer cells to T cell-mediated killing. Provided is a method of sensitizing cancer cells in a subject afflicted with a cancer to cytotoxic T cell-mediated killing comprising administering to the subject a therapeutically effective amount of an agent that modulates the copy number, amount, and/or activity of at least one biomarker. Further provided is a method of sensitizing cancer cells to cytotoxic T cell-mediated killing comprising contacting the cancer cells with 1 ) an agent that modulates the copy number, amount, and/or activity of at least one biomarker in the cancer cells and 2) cytotoxic T cells, thereby sensitizing the cancer cells to cytotoxic T cell-mediated killing, is provided. The present invention also encompasses kits for detecting and/or modulating biomarkers described herein.
(FR) La présente invention est basée, en partie, sur l'identification, de nouveaux biomarqueurs, et des méthodes de modulation de ceux-ci, pour sensibiliser des cellules cancéreuses à la destruction par des lymphocytes T.
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指定国: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
非洲地区知识产权组织 (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
欧亚专利局 (AM, AZ, BY, KG, KZ, RU, TJ, TM)
欧洲专利局 (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
非洲知识产权组织 (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
公布语言: 英语 (EN)
申请语言: 英语 (EN)