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1. (WO2018211413) SOLID FORMS OF OBETICHOLIC ACID AND PROCESS FOR PREPARATION
国际局存档的最新著录项目数据提交意见

公布号: WO/2018/211413 国际申请号: PCT/IB2018/053377
公布日: 22.11.2018 国际申请日: 15.05.2018
国际专利分类:
A61K 31/575 (2006.01) ,C07J 9/00 (2006.01) ,A61P 1/16 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
56
Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
575
substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
C 化学;冶金
07
有机化学
J
甾族化合物
9
含有碳、氢、卤素或氧的正系甾族化合物,在17β位上被1条多于两个碳原子的链所取代,如胆烷、胆甾烷、粪甾烷
A 人类生活必需
61
医学或兽医学;卫生学
P
化合物的治疗活性
1
治疗消化道或消化系统疾病的药物
16
治疗肝脏或胆囊疾病的药物,例如保肝药、利胆药、溶石药
申请人:
DR. REDDY’S LABORATORIES LIMITED [IN/IN]; 8-2-337, Road No. 3, Banjara Hills Hyderabad, Telangana 500034, IN
发明人:
PATHIVADA, Deepika; IN
MUDAPAKA, Vamsi Krishna; IN
GUPTA, Anish; IN
优先权数据:
20174101689115.05.2017IN
标题 (EN) SOLID FORMS OF OBETICHOLIC ACID AND PROCESS FOR PREPARATION
(FR) FORMES SOLIDES D'ACIDE OBÉTICHOLIQUE ET PROCÉDÉ DE PRÉPARATION ASSOCIÉ
摘要:
(EN) The invention of the present application relates to crystalline forms of obeticholic acid and process for preparation thereof. Specifically, the invention of present application relates to crystalline forms VD1, VD2, VD3, VD4 and VD5 of obeticholic acid. Specifically, crystalline form VD2 is stable and has excellent physic-chemical properties. Crystalline form VD2 is may be easily formulated into a pharmaceutical composition comprising obeticholic acid.
(FR) La présente invention concerne des formes cristallines d'acide obéticholique et un procédé de préparation associé. Spécifiquement, l'invention concerne les formes cristallines VD1, VD2, VD3, VD4 et VD5 d'acide obéticholique. Spécifiquement, la forme cristalline VD2 est stable et présente d'excellentes propriétés physico-chimiques. La forme cristalline VD2 peut être facilement formulée en une composition pharmaceutique comprenant de l'acide obéticholique.
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指定国: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
非洲地区知识产权组织 (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
欧亚专利局 (EAPO) (AM, AZ, BY, KG, KZ, RU, TJ, TM)
欧洲专利局 (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
非洲知识产权组织 (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
公布语言: 英语 (EN)
申请语言: 英语 (EN)