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1. (WO2018198013) FLUOROGEN-BINDING RNA APTAMERS

Pub. No.:    WO/2018/198013    International Application No.:    PCT/IB2018/052808
Publication Date: Fri Nov 02 00:59:59 CET 2018 International Filing Date: Tue Apr 24 01:59:59 CEST 2018
IPC: C12N 15/115
C12Q 1/68
Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
UNIVERSITÉ DE STRASBOURG
SIMON FRASER UNIVERSITY
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Inventors: RYCKELYNK, Michaël
AUTOUR, Alexis
UNRAU, Peter
DOLGOSHEINA, Elena
JENG, Sunny Chiu Yuk
PANCHAPAKESAN, Shanker Shyam Sundhar
ABDOLAHZADEH, Amir
COJOCARU, Razvan
FERRÉ D'AMARÉ, Adrian
TRACHMAN, Robert
Title: FLUOROGEN-BINDING RNA APTAMERS
Abstract:
RNA aptamers are disclosed with distinct fluorescent properties, fluorophore binding affinities, and salt dependence. Also disclosed are corresponding fluorophores, with selected fluorophores evidencing high cellular permeability. The aptamer's high fluorophore affinities, the high brightness of the bound complexes, and their thermal and salt stability, provide distinct aspects of the disclosed aptamers.