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1. (WO2018145620) SULPHAMOYLARYL DERIVATIVES AND USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF LIVER FIBROSIS



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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/CN2018/075362 P2018TC436
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
06 February 2018 07 February 2017
Applicant
Janssen Pharmaceutica NV et al
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing filed or furnished:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     A61K 31/165 (2006.01)i; A61K 31/18 (2006.01)i; A61P 1/16 (2006.01)i; C07C 311/16 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     A61K; A61P; C07C
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
CNABS, CNMED, CNKI, DWPI, SIPOABS, USTXT, WOTXT, EPTXT, CATXT, JPTXT, REGISTRY(STN), MARPAT(STN), CAPLUS(STN): SULPHAMOYLARYL, SULPHAMOYL, SULPHAMOYL ARYLAMIDE, FIBROSIS, CIRRHOSIS, LIVER, HT2B, HYDROXYTRYPTAMINE, Janssen Pharmaceutica

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
WO 2014106019 A2 (PHILADELPHIA HEALTH & EDUCATIOET AL.) 03 July 2014 (2014-07-03)
1-5, 11
claims 1-61, description paragraph 0505
(2)
A
WO 2013096744 A1 (NOVIRA THERAPEUTICS INC) 27 June 2013 (2013-06-27)
1-12
claims 1-37
(3)
A
WO 2013006394 A1 (INST HEPATITIS & VIRUS RESET AL.) 10 January 2013 (2013-01-10)
1-12
claim 1
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
WO 2014106019 A2
03 July 2014
AU 2013370300 A1
MX 2015008471 A
WO 2014106019 A3
CA 2896554 A1
KR 20150114480 A
EP 2938338 A2
EA 201591220 A1
IL 239397 D0
EP 2938338 A4
US 2016024004 A1
PH 12015501473 A1
CN 105209031 A
SG 11201504740U A
HK 1217649 A1
JP 2016509591 A
IL 239397 A
02 July 2015
26 October 2016
18 September 2014
03 July 2014
12 October 2015
04 November 2015
29 January 2016
30 July 2015
23 November 2016
28 January 2016
21 September 2015
30 December 2015
30 July 2015
20 January 2017
31 March 2016
30 July 2015
WO 2013096744 A1
27 June 2013
EP 2794565 A4
TW 201604179 A
TW I519515 B
KR 101699822 B1
US 8629274 B2
AU 2016231615 A1
US 2014179665 A1
TW I580668 B
TW 201728571 A
AU 2012358332 C1
SG 11201402660Y A
EP 2794565 A1
US 2017334882 A1
US 9676747 B2
EA 026368 B1
US 9061008 B2
IL 233182 D0
NZ 625614 A
SG 10201608528Y A
KR 20140138602 A
US 9066932 B2
US 2015259324 A1
AU 2012358332 A1
CA 2857344 A1
JP 2016222693 A
US 9751857 B2
CN 104144913 B
EA 201691837 A1
CN 104144913 A
CN 106957282 A
DK 2794565 T3
EP 2794565 B1
US 2014178337 A1
TW 201336814 A
KR 20170010109 A
AU 2012358332 B2
MX 2014007261 A
PH 12014501314 A1
EA 201491223 A1
JP 5977837 B2
JP 2015506927 A
US 2015152073 A1
CL 2014001463 A1
AR 090044 A1
US 2013251673 A1
ES 2649410 T3
CO 7051027 A2
24 June 2015
01 February 2016
01 February 2016
25 January 2017
14 January 2014
20 October 2016
26 June 2014
01 May 2017
16 August 2017
19 January 2017
30 October 2014
29 October 2014
23 November 2017
13 June 2017
31 March 2017
23 June 2015
03 August 2014
28 October 2016
29 December 2016
04 December 2014
30 June 2015
17 September 2015
17 July 2014
27 June 2013
28 December 2016
05 September 2017
17 May 2017
29 December 2017
12 November 2014
18 July 2017
13 November 2017
26 July 2017
26 June 2014
16 September 2013
25 January 2017
23 June 2016
06 March 2015
15 September 2014
30 January 2015
24 August 2016
05 March 2015
04 June 2015
26 December 2014
15 October 2014
26 September 2013
11 January 2018
10 September 2014
WO 2013006394 A1
10 January 2013
US 2016101074 A1
US 9399619 B2
US 2017320818 A1
EP 3085368 A1
US 9758477 B2
JP 2014523901 A
EP 2726459 A1
JP 5977347 B2
JP 2017014225 A
US 2014206666 A1
CN 103889953 B
CN 103889953 A
EP 2726459 A4
CN 106166157 A
14 April 2016
26 July 2016
09 November 2017
26 October 2016
12 September 2017
18 September 2014
07 May 2014
24 August 2016
19 January 2017
24 July 2014
08 June 2016
25 June 2014
31 December 2014
30 November 2016
Name and mailing address of the ISA/:
STATE INTELLECTUAL PROPERTY OFFICE OF THE P.R.CHINA
6, Xitucheng Rd., Jimen Bridge, Haidian District, Beijing 100088
China
Facsimile No. (86-10)62019451
Date of the actual completion of the international search:
27 March 2018
Date of mailing of the international search report:
08 May 2018
Authorized officer:
ZHANG,Zhonghui
Telephone No. (86-10)62089324
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