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1. (WO2018089423) CD38-NAD+ REGULATED METABOLIC AXIS IN ANTI-TUMOR IMMUNOTHERAPY
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公布号: WO/2018/089423 国际申请号: PCT/US2017/060537
公布日: 17.05.2018 国际申请日: 08.11.2017
国际专利分类:
A61K 35/17 (2015.01) ,A61K 35/26 (2015.01) ,C07K 16/30 (2006.01) ,C12N 5/0783 (2010.01)
[IPC code unknown for A61K 35/17]
A 人类生活必需
61
医学或兽医学;卫生学
K
医用、牙科用或梳妆用的制剂
35
含有其有不明结构的原材料或其反应产物的医用配制品
12
来源于哺乳动物或鸟类的材料的
26
淋巴;淋巴腺;胸腺
C 化学;冶金
07
有机化学
K
16
免疫球蛋白,例如,单克隆或多克隆抗体
18
抗来自动物或人的物质
28
抗受体,细胞表面抗原或细胞表面决定因子
30
来自肿瘤细胞
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
078
Cells from blood or from the immune system
0783
T cells; NK cells; Progenitors of T or NK cells
申请人:
MUSC FOUNDATION FOR RESEARCH DEVELOPMENT [US/US]; 19 Hagood Avenue, Suite 909 Charleston, SC 29425, US
发明人:
MEHROTRA, Shikhar; US
CHATTERJEE, Shilpak; US
代理人:
BYRD, Marshall, P.; US
优先权数据:
62/419,61209.11.2016US
标题 (EN) CD38-NAD+ REGULATED METABOLIC AXIS IN ANTI-TUMOR IMMUNOTHERAPY
(FR) AXE MÉTABOLIQUE RÉGULÉ CD38-NAD+ EN IMMUNOTHÉRAPIE ANTITUMORALE
摘要:
(EN) The present disclosure provides methods of producing hybrid Th1/Th17 cells. Also provided herein are methods of treating cancer comprising targeting the CD38- mediated metabolic axis.
(FR) La présente invention concerne des procédés de production de cellules Th1/Th17 hybrides. L'invention concerne également des procédés de traitement du cancer comprenant le ciblage de l'axe métabolique médié par CD38.
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指定国: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
非洲地区知识产权组织 (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
欧亚专利局 (AM, AZ, BY, KG, KZ, RU, TJ, TM)
欧洲专利局 (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
非洲知识产权组织 (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
公布语言: 英语 (EN)
申请语言: 英语 (EN)