检索国际和国家专利汇编

1. (WO2017059397) LABELING OF ANTIBODIES

Pub. No.:    WO/2017/059397    International Application No.:    PCT/US2016/055074
Publication Date: Fri Apr 07 01:59:59 CEST 2017 International Filing Date: Sun Oct 02 01:59:59 CEST 2016
IPC: C07K 16/28
C07K 16/46
G01N 33/58
Applicants: WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUDETTS GENERAL HOSPITAL
Inventors: RASHIDIAN, Mohammad
PLOEGH, Hidde L.
VASDEV, Neil
LIANG, Huan Steven
Title: LABELING OF ANTIBODIES
Abstract:
Provided herein are methods for producing site specific PEG modifications to single domain antibodies (e.g., VHHs). Methods for producing site- specific ally conjugated bivalent single domain antibodies (e.g., VHHs) are also provided. Methods for labeling (e.g., with a fluorophore or radionuclide) site-specifically PEGylated single domain antibodies and site- specifically conjugated bivalent single domain antibodies are also provided.