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1. (WO2015100144) CRYSTALLINE FORMS OF A MACROCYCLIC HCV NS3 INHIBITING TRIPEPTIDE
国际局存档的最新著录项目数据

公布号: WO/2015/100144 国际申请号: PCT/US2014/071310
公布日: 02.07.2015 国际申请日: 18.12.2014
国际专利分类:
C07K 5/12 (2006.01)
C 化学;冶金
07
有机化学
K
5
在完全确定的序列中含有最多4个氨基酸的肽;其衍生物
04
仅含有正常肽键
12
环肽
申请人:
GILEAD SCIENCES, INC. [US/US]; 333 Lakeside Drive Foster City, California 94404, US
发明人:
BRINGLEY, Dustin; US
CHAN, Johann; US
FUNG, Peter; US
KEATON, Katie; US
LAPINA, Olga; US
MORRISON, Henry; US
PCION, Dominika; US
代理人:
TANNER, Lorna L.; US
优先权数据:
61/920,42723.12.2013US
标题 (EN) CRYSTALLINE FORMS OF A MACROCYCLIC HCV NS3 INHIBITING TRIPEPTIDE
(FR) FORMES CRISTALLINES D'UN COMPOSÉ ANTIVIRAL
摘要:
(EN) Crystalline forms of the anti-HCV compound (1R,5S,8S,9S,10R,22aR )-5-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-9-ethyl-18,18-difluoro-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6] dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxamide (Compound I) were prepared and characterized in the solid state. Also provided are processes of manufacture and methods of using the crystalline forms.
(FR) Formes cristallines du composé anti-VHC (1aR,5S,8S,9S,10R,22aR )-5-tert-butyl-N-[(1R,2R)-2-(difluorométhyl)-1-{[(1-méthylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-9-éthyl-18,18-difluoro-14-méthoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tétradécahydro-8H-7,10-méthanocyclopropa[18,19][1,10,3,6] dioxadiazacyclononadécino[11,12-b]quinoxaline-8-carboxamide (composé I) qui ont été préparées et qui sont caractérisées à l'état solide. L'invention concerne également des procédés de fabrication et des procédés d'utilisation desdites formes cristallines.
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指定国: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
非洲地区知识产权组织 (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
欧亚专利局 (EAPO) (AM, AZ, BY, KG, KZ, RU, TJ, TM)
欧洲专利局 (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
非洲知识产权组织 (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
公布语言: 英语 (EN)
申请语言: 英语 (EN)
也发表为:
UY0001035918CA2934049EP3087086JP2017503016AU2014370124ES2708993