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31. (WO2012030953) 5-HT2C RECEPTOR AGONISTS IN THE TREATMENT OF DISORDERS AMELIORATED BY REDUCTION OF NOREPINEPHRINE LEVEL

Pub. No.:    WO/2012/030953    International Application No.:    PCT/US2011/049955
Publication Date: Fri Mar 09 00:59:59 CET 2012 International Filing Date: Thu Sep 01 01:59:59 CEST 2011
IPC: A61K 31/00
A61K 31/55
Applicants: ARENA PHARMACEUTICALS, INC.
ANDERSON, Christen, M.
SHANAHAN, William, R.
Inventors: ANDERSON, Christen, M.
SHANAHAN, William, R.
Title: 5-HT2C RECEPTOR AGONISTS IN THE TREATMENT OF DISORDERS AMELIORATED BY REDUCTION OF NOREPINEPHRINE LEVEL
Abstract:
Uses of 5-HT2C receptor agonists in the treatment of disorders ameliorated by reduction of an individual's norepinephrine level, wherein said disorders include but are not limited to hypernorepinephrinemia, cardiomyopathy, cardiac hypertrophy, cardiomyocyte hypertrophy in post-myocardial infarction remodeling, elevated heart rate, vasoconstriction, acute pulmonary vasoconstriction, hypertension, heart failure, cardiac dysfunction after stroke, cardiac arrhythmia, metabolic syndrome, abnormal lipid metabolism, hyperthermia, Cushing syndrome, pheochromocytoma, epilepsy, obstructive sleep apnea, insomnia, glaucoma, osteoarthritis, rheumatoid arthritis, and asthma.