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1. (WO2006119675) 一种作为抗肿瘤药物应用的酪氨酸激酶抑制剂及其制备方法

Pub. No.:    WO/2006/119675    International Application No.:    PCT/CN2005/000662
Publication Date: 2006-11-16 International Filing Date: 2005-5-12
IPC: C07D 239/94
A61K 31/505
A61P 35/00
Applicants: HUANG, Wenlin
黄文林
ZHOU, Xiaohong
周晓虹
Inventors: HUANG, Wenlin
黄文林
ZHOU, Xiaohong
周晓虹
Title: 一种作为抗肿瘤药物应用的酪氨酸激酶抑制剂及其制备方法
Abstract:
Provided are quinazoline derivatives of the compound (I), and its preparation process and application as a medicine of inhibit tumor growth. The group X, Y, Z, R1, R2, R3, R4 of compound (I) are defined in the description. Compounds of the invention can selectively inhibit the phosphorylation of tyrosine kinase, and block the signal transduction path of tyrosine kinase, specially inhibit tyrosine kinase activity, thus to have the effect of inhibit the tumor vascularization, achieve the purpose of treating malignant tumor.