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1. (WO2003004470) CRYSTALLINE FORMS OF 'R-(R*,R*)!-2-(4-FLUOROPHENYL)-BETA, DELTA-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-'PHENYLAMINO)CARBONYL!-1H-PYRROLE-1-HEPTANOIC ACID CALCIUM SALT (2:1) (ATORVASTATIN)
国际局存档的最新著录项目数据   

公布号: WO/2003/004470 国际申请号: PCT/IB2002/001796
公布日: 16.01.2003 国际申请日: 21.05.2002
第2章国际初步审查要求书已提交: 17.07.2002
国际专利分类:
C07D 207/34 (2006.01)
C 化学;冶金
07
有机化学
D
杂环化合物(高分子化合物入C08)
207
杂环化合物,含五元环,不与其他环稠合,带1个氮原子作为惟一的环杂原
02
只有氢或碳原子直接连在环氮原子上
30
环原子间或环原子与非环原子间有两个双键
34
有杂原子或有以3个键连杂原子、其中最多以1个键连卤素的碳原子,例如,酯基或腈基,直接连在环碳原子上
申请人:
BYRN, Stephen, Robert [US/US]; US (UsOnly)
COATES, David, Andrew [US/US]; US (UsOnly)
GUSHURST, Karen, Sue [US/US]; US (UsOnly)
MORRISON, Henry, Grant, II [US/US]; US (UsOnly)
PARK, Aeri [KR/US]; US (UsOnly)
VLAHOVA, Petinka Ivanova [BG/US]; US (UsOnly)
LI, Zheng, Jane [US/US]; US (UsOnly)
KRZYZANIAK, Joseph, Francis [US/US]; US (UsOnly)
WARNER-LAMBERT COMPANY LLC [US/US]; 201 Tabor Road Morris Plains, NJ 07950, US (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NE, NL, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZM, ZW)
发明人:
BYRN, Stephen, Robert; US
COATES, David, Andrew; US
GUSHURST, Karen, Sue; US
MORRISON, Henry, Grant, II; US
PARK, Aeri; US
VLAHOVA, Petinka Ivanova; US
LI, Zheng, Jane; US
KRZYZANIAK, Joseph, Francis; US
代理人:
LUMB, J., Trevor; Pfizer Inc. 201 Tabor Road Morris Plains, NJ 07950, US
优先权数据:
60/302,04929.06.2001US
标题 (EN) CRYSTALLINE FORMS OF 'R-(R*,R*)!-2-(4-FLUOROPHENYL)-BETA, DELTA-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-'PHENYLAMINO)CARBONYL!-1H-PYRROLE-1-HEPTANOIC ACID CALCIUM SALT (2:1) (ATORVASTATIN)
(FR) FORMES CRISTALLINES DE SEL HEMICALCIQUE D'ACIDE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-BETA,DELTA-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1-HEPTANOIQUE (ATORVASTATINE)
摘要:
(EN) Novel crystalline forms of [R-(R*,R*)]-2-(4-fluorophenyl)-$g(b), Δ;-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemi calcium salt atorvastatin designated Form V, Form VI, Form VII, Form VIII, Form IX, Form X, Form XI, Form XII, Form XIII, Form XIV, Form XV, Form XVI, Form XVII, Form XVIII, and Form XIX are characterized by their X-ray powder diffraction, solid-state NMR, and/or Raman spectroscopy are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, and Alzheimer's disease.
(FR) L'invention concerne des nouvelles formes cristallines de sel hémicalcique d'acide [R-(R*,R*)]-2-(4-fluorophényl)-$g(b),$g(d)-dihydroxy-5-(1-méthyléthyl)-3-phényl-4-[(phénylamino)carbonyl]-1H-pyrrole-1-heptanoïque (atorvastatine), appelées Forme V, Forme VI, Forme VII, Forme VIII, Forme IX, Forme X, Forme XI, Forme XII, Forme XIII, Forme XIV, Forme XV, Forme XVI, Forme XVII, Forme XVIII et Forme XIX. Ces formes sont caractérisées par leur diffraction des rayons X sur poudre, leur NMR en phase solide et/ou leur spectroscopie Raman. L'invention concerne également des procédés de préparation et une composition pharmaceutique de ces formes, lesquelles sont utiles comme agents destinés à traiter l'hyperlipidémie, l'hypercholestérolémie, l'ostéoporose et la maladie d'Alzheimer.
指定国: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW
非洲地区知识产权组织 (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
欧亚专利局 (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
欧洲专利局 (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
非洲知识产权组织 (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
公布语言: 英语 (EN)
申请语言: 英语 (EN)