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1. (WO2002026696) CARBAMIC ACID COMPOUNDS COMPRISING AN AMIDE LINKAGE AS HDAC INHIBITORS
国际局存档的最新著录项目数据

公布号: WO/2002/026696 国际申请号: PCT/GB2001/004329
公布日: 04.04.2002 国际申请日: 27.09.2001
第2章国际初步审查要求书已提交: 26.04.2002
国际专利分类:
A61K 31/16 (2006.01) ,A61K 31/195 (2006.01) ,A61K 31/198 (2006.01) ,A61K 31/277 (2006.01) ,A61K 31/38 (2006.01) ,A61K 31/381 (2006.01) ,A61K 31/426 (2006.01)
A 人类生活必需
61
医学或兽医学;卫生学
K
医用、牙科用或梳妆用的制剂
31
含有机有效成分的医药配制品
16
酰胺,例如异羟肟酸
A 人类生活必需
61
医学或兽医学;卫生学
K
医用、牙科用或梳妆用的制剂
31
含有机有效成分的医药配制品
185
酸;酐、卤化物或其盐类,例如硫酸类、亚氨酸、腙酸或羟肟酸
19
羧酸;例如丙戊酸
195
含氨基的
A 人类生活必需
61
医学或兽医学;卫生学
K
医用、牙科用或梳妆用的制剂
31
含有机有效成分的医药配制品
185
酸;酐、卤化物或其盐类,例如硫酸类、亚氨酸、腙酸或羟肟酸
19
羧酸;例如丙戊酸
195
含氨基的
197
有与同一无环碳链相连的氨基和羧基的,例如γ氨基丁酸(GABA)、β丙氨酸、ε氨基己酸、泛酸
198
α-氨基酸,例如丙氨酸、乙二胺四乙酸(EDTA)
A 人类生活必需
61
医学或兽医学;卫生学
K
医用、牙科用或梳妆用的制剂
31
含有机有效成分的医药配制品
275
腈;异腈
277
有环的,例如维拉帕米
A 人类生活必需
61
医学或兽医学;卫生学
K
医用、牙科用或梳妆用的制剂
31
含有机有效成分的医药配制品
33
杂环化合物
38
有硫作为环杂原子的
A 人类生活必需
61
医学或兽医学;卫生学
K
医用、牙科用或梳妆用的制剂
31
含有机有效成分的医药配制品
33
杂环化合物
38
有硫作为环杂原子的
381
五元环的
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
426
1,3-Thiazoles
申请人:
PROLIFIX LIMITED [GB/GB]; 91 Milton Park Abingdon, Oxfordshire OX14 4RY, GB (AllExceptUS)
WATKINS, Clare, J. [GB/GB]; GB (UsOnly)
ROMERO-MARTIN, Maria-Rosario [ES/GB]; GB (UsOnly)
MOORE, Kathryn, G. [GB/GB]; GB (UsOnly)
RITCHIE, James [GB/GB]; GB (UsOnly)
FINN, Paul, W. [GB/GB]; GB (UsOnly)
KALVINSH, Ivars [LV/LV]; LV (UsOnly)
LOZA, Einars [LV/LV]; LV (UsOnly)
STARCHENKOV, Igor; LV (UsOnly)
DIKOVSKA, Klara [LV/LV]; LV (UsOnly)
BOKALDERE, Rasma, Melita [LV/LV]; LV (UsOnly)
GAILITE, Vija [LV/LV]; LV (UsOnly)
VORONA, Maxim [LV/LV]; LV (UsOnly)
ANDRIANOV, Victor [--/LV]; LV (UsOnly)
LOLYA, Daina [LV/LV]; LV (UsOnly)
SEMENIKHINA, Valentina; LV (UsOnly)
AMOLINS, Andris [LV/LV]; LV (UsOnly)
HARRIS, C., John, [GB/GB]; GB (UsOnly)
DUFFY, James, E., S. [GB/GB]; GB (UsOnly)
发明人:
WATKINS, Clare, J.; GB
ROMERO-MARTIN, Maria-Rosario; GB
MOORE, Kathryn, G.; GB
RITCHIE, James; GB
FINN, Paul, W.; GB
KALVINSH, Ivars; LV
LOZA, Einars; LV
STARCHENKOV, Igor; LV
DIKOVSKA, Klara; LV
BOKALDERE, Rasma, Melita; LV
GAILITE, Vija; LV
VORONA, Maxim; LV
ANDRIANOV, Victor; LV
LOLYA, Daina; LV
SEMENIKHINA, Valentina; LV
AMOLINS, Andris; LV
HARRIS, C., John,; GB
DUFFY, James, E., S.; GB
代理人:
ARMITAGE, Ian, M. ; Mewburn Ellis York House 23 Kingsway London WC2B 6HP, GB
ADRIAN H. BRASNETT and others Mewburn Ellis; York House 23 Kingsway London WC2B 6HP, GB
优先权数据:
0023985.529.09.2000GB
60/297,78514.06.2001US
标题 (EN) CARBAMIC ACID COMPOUNDS COMPRISING AN AMIDE LINKAGE AS HDAC INHIBITORS
(FR) COMPOSES D'ACIDE CARBAMIQUE COMPRENANT UN ENCHAINEMENT AMIDE COMME INHIBITEURS HDAC
摘要:
(EN) This invention pertains to certain active carbamic acid compounds which inhibit HDAC activity and which have the formula (1) wherein: A is an aryl group; Q1 is an aryl leader group having a backbone of at least 2 carbon atoms; J is an amide linkage selected from: -NR1C(=O)- and -C(=O)NR1-; R1 is an amido substituent; and, Q2 is an acid leader group; and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HDAC, and, e.g., to inhibit proliferative conditions, such as cancer and psoriasis.
(FR) L'invention concerne certains composés d'acide carbamique actifs inhibant l'activité HDAC et correspondant à la formule (1), dans laquelle A désigne un groupe aryle ; Q1 désigne un groupe leader aryle ayant un squelette d'au moins 2 atomes de carbone; J désigne un enchaînement amide choisi à partir de: -NR1C(=O)- et-C(=O)NR1-; R1 désigne un substituant amido; et Q2 désigne un groupe leader acide ; ainsi que les sels, solvates, amides, esters, éthers pharmaceutiquement acceptables, les formes protégés chimiquement et les promédicaments de ces composés. L'invention concerne en outre des compositions pharmaceutiques comprenant de tels composés, ainsi que l'utilisation de ces composés et de ces compositions, à la fois in vitro et in vivo, en vue d'inhiber HDAC et d'inhiber, par exemple, des états de proliférations tels que cancers et psoriasis.
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指定国: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
非洲地区知识产权组织 (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
欧亚专利局 (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
欧洲专利局 (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
非洲知识产权组织 (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
公布语言: 英语 (EN)
申请语言: 英语 (EN)