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1. (US20170129959) Antibodies directed against CD127

专利局 : 美国
申请号: 15317355 申请日: 10.06.2015
公布号: 20170129959 公布日: 11.05.2017
授权号: 10428152 授权日: 01.10.2019
公布类型: B2
专利合作条约参考号: 申请号:PCTEP2015062993;公布号: 单击查看数据
国际专利分类:
C07K 16/28
C12N 15/63
G01N 33/50
A61K 39/00
C 化学;冶金
07
有机化学
K
16
免疫球蛋白,例如,单克隆或多克隆抗体
18
抗来自动物或人的物质
28
抗受体,细胞表面抗原或细胞表面决定因子
C 化学;冶金
12
包括微生物或酶的生物化学、微生物学、酶学,它们的制备;用其来合成化合物或组合物;涉及微生物或酶的测定或检验方法;变异或遗传工程
N
微生物或酶;其组合物;繁殖、保藏或维持微生物;变异或遗传工程;培养基
15
突变或遗传工程;遗传工程涉及的DNA或RNA,载体(如质粒)或其分离、制备或纯化;所使用的宿主
09
Recombinant DNA-technology
63
使用载体引入外来遗传物质;载体;其宿主的使用;表达的调节
G PHYSICS
01
用于测量的传感器,如敏感元件
N
借助于测定材料的化学或物理性质来测试或分析材料
33
利用不包括在G01N 1/00至G01N 31/00组中的特殊方法来研究或分析材料
48
生物物质,例如血、尿;血球计数器
50
生物物质(例如血、尿)的化学分析;包括了生物特有的配体结合方法的测试;免疫学试验
A 人类生活必需
61
医学或兽医学;卫生学
K
医用、牙科用或梳妆用的制剂
39
含有抗原或抗体的医药配制品
CPC:
G01N 33/5041
C07K 16/2866
A61K 2039/505
C07K 2317/24
C07K 2317/34
C07K 2317/732
C07K 2317/76
C07K 2317/77
C07K 2317/92
C07K 2317/94
G01N 2333/5418
G01N 2333/70546
G01N 2333/7155
G01N 2500/00
申请人: OSE IMMUNOTHERAPEUTICS
发明人: Nicolas Poirier
Caroline Mary
Bernard Vanhove
代理人: Thompson Coburn LLP
Charles P. Romano
优先权数据: 15305078 23.01.2015 EP
标题: (EN) Antibodies directed against CD127
摘要: front page image
(EN)

The invention relates to antibodies directed against CD127, the alpha chain of the interleukin 7 (IL-7) receptor IL-7R), and which have antagonist properties for IL-7-IL-7R interaction, may present cytotoxic activity against CD127 positive cells but do not increase the maturation of dendritic cells (DCs) induced by TSLP, a cytokine also using CD127 as part of its receptor. Alternatively, or in addition, these antibodies do not induce the internalization of CD127 and/or inhibit the IL7-induced internalization of CD127. According to another aspect of the invention antibodies are provided which recognize a human CD127 epitope comprising sequences from the 2b site of CD127, in particular the epitope comprising comprises the human CD127 sequences of domain D1 and of the 2b site of CD127, in particular the epitope comprises at least one sequence from D1 comprising SEQ ID No: 115 (in particular comprising SEQ ID No: 10) and/or SEQ ID No: 111 and/or a sequence from the 2b site comprising the sequence of SEQ ID No: 116 and optionally also comprises SEQ ID No: 117 (in particular comprises SEQ ID No: 111). The antibodies of the invention are suitable for use in order to remedy to a condition diagnosed in a human patient which results from pathogenesis related to lymphopoiesis, when IL-7 signalling pathways provide contribution to said pathogenesis, especially when an increase in the maturation, more precisely the upregulation of costimulatory molecules, of dendritic cells is undesirable.


也发表为:
UAa201613258SG11201610036PCA2950823AU2015273532EP3155014KR1020170019417
IL249449CN106715471VN52585MYPI 2016002094PH1/2016/502445JP2017522903
TH171839IN201617042413BR112016028755TN2016000528EA201692460RU2016151265
CR20160576WO/2015/189302