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1. (NZ613087) HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF

专利局 : 新西兰
申请号: 613087 申请日: 23.01.2012
公布号: 613087 公布日: 27.02.2015
授权号: 授权日: 28.05.2015
公布类型: B
专利合作条约参考号: 申请号:PCTUS2012022216;公布号: 单击查看数据
国际专利分类:
A01N 37/08
A61K 31/19
A 人类生活必需
01
农业;林业;畜牧业;狩猎;诱捕;捕鱼
N
杀生剂
37
含有机化合物的杀生剂、害虫驱避剂或引诱剂,或植物生长调节剂,该有机化合物含带有3个连于杂原子的键的碳原子,其中至多有两个键连于卤素,例如羧酸
08
含有羧基或其硫代类似物,由碳原子直接连于环脂族环;其衍生物
A 人类生活必需
61
医学或兽医学;卫生学
K
医用、牙科用或梳妆用的制剂
31
含有机有效成分的医药配制品
185
酸;酐、卤化物或其盐类,例如硫酸类、亚氨酸、腙酸或羟肟酸
19
羧酸;例如丙戊酸
申请人: CHDI FOUNDATION, INC.
发明人: LUCKHURST, Christopher A.
HAUGHAN, Alan F.
BRECCIA, Perla
STOTT, Andrew J.
BURLI, Roland W.
HUGHES, Samantha J.
MUNOZ-SANJUAN, Ignacio
DOMINGUEZ, Celia
MANGETTE, John E.
代理人: DAVIES COLLISON CAVE
优先权数据: 61/435,678 24.01.2011 US
标题: (EN) HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF
摘要:
(EN) The disclosure relates to substituted phenylcyclopropanecarboxamide derivatives of formula (I) and pharmaceutically acceptable salt thereof, which are histone deacetylase (HDAC) inhibitors, wherein the variables are as defined in the specification. These compounds of formula (I) are suitable for treating a condition or disorder mediated by at least one histone deacetylase in a subject, and therefore useful for treating a neurodegenerative pathology, particularly Huntington's disease.
也发表为:
CA2824078JP2014511355EP2667709US20140163009CN103429079SG192061
AR085088MX2013008629RU2013136778KR1020140037821AU2012209312PH1/2013/501561
IN6588/DELNP/2013WO/2012/103008