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1. (WO2001014036) PROCESS FOR PRODUCING FINE MEDICINAL SUBSTANCES

Pub. No.:    WO/2001/014036    International Application No.:    PCT/GB2000/003178
Publication Date: Fri Mar 02 00:59:59 CET 2001 International Filing Date: Sat Aug 19 01:59:59 CEST 2000
IPC: A61K 9/16
B01D 9/00
B01F 3/08
B01F 5/00
B01F 5/02
B01F 13/00
Applicants: AVENTIS PHARMA LIMITED
BEGON, Dominique
GUILLAUME, Pfefer
KOHL, Michael
Inventors: BEGON, Dominique
GUILLAUME, Pfefer
KOHL, Michael
Title: PROCESS FOR PRODUCING FINE MEDICINAL SUBSTANCES
Abstract:
The method of producing fine medicament particles suitable for inhalation, particles produced by the method and apparatus suitable for carrying out the method is claimed. The method comprises contacting a stream or streams of a solution of medicament with a stream or streams of a liquid in which the medicament is insoluble in a confined chamber such that a region of intense turbulence and mixing is formed. The medicament crystallises as fine particles with minimal inclusion of solvent or anti-solvent impurities. The crystallised medicament is separated from suspension by standard techniques. Careful control of relative stream velocity, solution concentration and proportion of solution and anti-solvent in the streams ensures a uniform product.