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1. (WO2007011623) QUINAZOLINE DERIVATIVES USEFUL IN CANCER TREATMENT
国际局存档的最新著录项目数据   

Translation翻译: 原语言 --> 中文
公布号:    WO/2007/011623    国际申请号:    PCT/US2006/027114
公布日: 25.01.2007 国际申请日: 13.07.2006
国际专利分类:
C07D 239/94 (2006.01), C07D 401/04 (2006.01), C07D 403/04 (2006.01), C07D 401/12 (2006.01), C07D 403/12 (2006.01), C07D 405/12 (2006.01), C07D 409/12 (2006.01), C07D 413/12 (2006.01), C07D 417/12 (2006.01), A61K 31/495 (2006.01)
申请人: SCHERING CORPORATION [US/US]; 2000 Galloping Hill Road, Kenilworth, New Jersey 07033-0530 (US) (For All Designated States Except US).
MALLAMS, Alan, K. [US/US]; (US) (For US Only).
DASMAHAPATRA, Bimalendu [US/US]; (US) (For US Only).
NEUSTADT, Bernard, R. [US/US]; (US) (For US Only).
DEMMA, Mark [US/US]; (US) (For US Only).
VACCARO, Henry, A. [US/US]; (US) (For US Only)
发明人: MALLAMS, Alan, K.; (US).
DASMAHAPATRA, Bimalendu; (US).
NEUSTADT, Bernard, R.; (US).
DEMMA, Mark; (US).
VACCARO, Henry, A.; (US)
代理人: BANERJEE, Krishna, G.; Schering-plough Corporation, 2000 Galloping Hill Road, Patent Dept. K-6-1 1990, Kenilworth, New Jersey 07033-0530 (US)
优先权数据:
60/700,058 15.07.2005 US
标题 (EN) QUINAZOLINE DERIVATIVES USEFUL IN CANCER TREATMENT
(FR) DERIVES DE QUINAZOLINE UTILES POUR TRAITER LE CANCER
摘要: front page image
(EN)The present invention provides compounds of Formula I (wherein X, m, R1, R2, R3, and R4 are as defined herein), or a pharmaceutically acceptable salt, solvate or ester thereof. The present invention also provides compositions comprising these compounds that are useful for treating cellular proliferative diseases, disorders associated with activity of mutants of p53, or in causing apoptosis of cancer cells.
(FR)La présente invention concerne des composés de formule I (dans laquelle X, m, R1, R2, R3, et R4 sont tels que définis dans l'invention), ou un sel, solvate ou ester de ceux-ci, acceptable d'un point de vue pharmaceutique. L'invention a également pour objet des compositions comprenant ces composés, utiles pour traiter des troubles de prolifération cellulaire, des troubles associés à l'activité de formes mutantes de p53, ou pour provoquer l'apoptose de cellules cancéreuses.
指定国: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
公布语言: English (EN)
申请语言: English (EN)