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1. (WO2002081709) MODIFIED HPV E6 AND E7 GENES AND PROTEINS USEFUL FOR VACCINATION

Pub. No.:    WO/2002/081709    International Application No.:    PCT/EP2002/003271
Publication Date: Fri Oct 18 01:59:59 CEST 2002 International Filing Date: Sat Mar 23 00:59:59 CET 2002
IPC: A61K 39/00
A61K 39/12
C07K 14/025
C12N 15/62
Applicants: DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFENTLICHEN RECHTS
CID-ARREGUI, Angel
ZUR HAUSEN, Harald
Inventors: CID-ARREGUI, Angel
ZUR HAUSEN, Harald
Title: MODIFIED HPV E6 AND E7 GENES AND PROTEINS USEFUL FOR VACCINATION
Abstract:
Described are DNA sequences encoding an E6 or E7 fusionprotein of HPV, wherein said DNA sequences are characterized by a combination of the following features: original codons are exchanged by codons which lead to an enhanced translation in a mammalian cell, they contain a deletion resulting in the production of a truncated non-functional protein, and they encode a fusionpartner which is a highly immunogenic polypeptide capable of enhancing the immunogenicity of the E6 or E7 protein in the mammalian host. Furthermore, the modified E6 or E7 protein encoded by said DNA sequences as well as expression vectors containing said DNA sequences are described as well as several uses of the these compounds.