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Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/EP2018/076669 UNA-025
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
01 October 2018 29 September 2017
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
1. With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
a. forming part of the international application as filed:
in the form of an Annex C/ST.25 text file.
on paper or in the form of an image file.
b. furnished together with the international application under PCT Rule 13ter.1(a) for the purposes of international search only in the form of an Annex C/ST.25 text file.
c. furnished subsequent to the international filing date for the purposes of international search only:
in the form of an Annex C/ST.25 text file (Rule 13ter.1(a)).
on paper or in the form of an image file (Rule 13ter.1(b) and Administrative Instructions, Section 713).
In addition, in the case that more than one version or copy of a sequence listing has been filed or furnished, the required statements that the information in the subsequent or additional copies is identical to that forming part of the application as filed or does not go beyond the application as filed, as appropriate, were furnished.
Additional comments:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
none of the figures is to be published with the abstract.


     A61K 39/155 (2006.01)i; C07K 14/005 (2006.01)i; C07K 14/135 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC


Minimum documentation searched (classification system followed by classification symbols):
     A61K; C07K; C12N
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):


Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
G. ZIMMER ET AL, "N-Glycans of F Protein Differentially Affect Fusion Activity of Human Respiratory Syncytial Virus", JOURNAL OF VIROLOGY.,Vol. 75, No. 10, 15 May 2001 (2001-05-15), page 4744-4751,
cited in the application
page 4749, column 2, paragraph 3 - page 4750; figures 1,2; tables 1,2
ZIMMER G ET AL, "Proteolytic activation of respiratory syncytial virus fusion protein: Cleavage at two furin consensus sequences", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US,Vol. 276, No. 34, 24 August 2001 (2001-08-24), page 31642-31650,
page 31645, column 2; figures 1,3
KLINK H A ET AL, "Influence of bovine respiratory syncytial virus F glycoprotein N-linked glycans on in vitro expression and on antibody responses in BALB/c mice", 12 April 2006 (2006-04-12), Vol. 24, No. 16, page 3388-3395,
[retrieved on  2006-04-12]
page 3391, column 2, paragraph 3
page 3392, column 1, paragraph 3 - page 3393, column 1, paragraph 1; figures 2,4; table 1
WO 2013049342 A1 (NOVAVAX INC [US]; SMITH GALE [US]; WU YINGYUN [US]; MASSARE MICHAEL [U) 04 April 2013 (2013-04-04)
paragraph [0011]
paragraph [0018] - paragraph [0022]
claims 13-19,3053-55,67-71; figures 1,2,7,16; examples 3,10
WO 2010111687 A2 (ACADEMIA SINICA; WONG CHI-HUEY [US]; MA CHE; WANG CHENG-CHI; CHEN JUIN) 30 September 2010 (2010-09-30)
paragraph [0163] - paragraph [0167]; claims 21,49,70
MCDONALD T P ET AL, "Evidence that maturation of the N-linked glycans of the respiratory syncytial virus (RSV) glycoproteins is required for virus-mediated cell fusion: The effect of @a-mannosidase inhibitors on RSV infectivity", 05 July 2006 (2006-07-05), Vol. 350, No. 2, page 289-301,
[retrieved on  2006-07-05]
WO 2014140083 A1 (MUCOSIS BV [NL]) 18 September 2014 (2014-09-18)
page 3, line 5 - page 4, line 8; figures 1-4
WO 2010149743 A2 (ID BIOMEDICAL CORP QUEBEC [CA]; GLAXOSMITHKLINE BIOLOG SA [BE]; BLAIS) 29 December 2010 (2010-12-29)
paragraph [0063] - paragraph [0065]
ESPOSITO SUSANNA ET AL, "Respiratory syncytial virus vaccines: an update on those in the immediate pipeline", FUTURE MICROBIOLOGY, FUTURE MEDICINE LTD, GB,Vol. 11, No. 11, 30 September 2016 (2016-09-30), page 1479-1490,
page 1484, column 2, paragraph 3 - page 1485, column 2, paragraph 2; table 1
Special categories of cited documents:
document defining the general state of the art which is not considered to be of particular relevance
earlier application or patent but published on or after the international filing date
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
document referring to an oral disclosure, use, exhibition or other means
document published prior to the international filing date but later than the priority date claimed
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
document member of the same patent family


Patent document cited in search report Publication date
Patent family member(s) Publication date
WO 2013049342 A1
04 April 2013
AU 2013201495 A1
BR 112014007616 A2
CA 2849471 A1
CN 104080476 A
CN 105381457 A
EP 2760469 A1
HK 1222125 A1
JP 2014530010 A
KR 20140077169 A
RU 2014117068 A
SG 10201602434U A
SG 11201400999V A
US 2013122032 A1
US 2015306207 A1
US 2015335730 A1
US 2017319682 A1
WO 2013049342 A1
18 April 2013
04 April 2017
04 April 2013
01 October 2014
09 March 2016
06 August 2014
23 June 2017
17 November 2014
23 June 2014
10 November 2015
30 May 2016
30 July 2014
16 May 2013
29 October 2015
26 November 2015
09 November 2017
04 April 2013
WO 2010111687 A2
30 September 2010
AU 2010229675 A1
AU 2016203431 A1
BR PI1012635 A2
CA 2756206 A1
CL 2014002415 A1
CN 103200961 A
CN 107375919 A
CO 6460701 A2
EP 2411049 A2
IL 215430 A
KR 20140014348 A
KR 20170124619 A
TW 201102084 A
US 2010247571 A1
US 2015335728 A1
WO 2010111687 A2
27 October 2011
16 June 2016
21 June 2016
30 September 2010
02 January 2015
10 July 2013
24 November 2017
15 June 2012
01 February 2012
30 November 2016
06 February 2014
10 November 2017
16 January 2011
30 September 2010
26 November 2015
30 September 2010
WO 2014140083 A1
18 September 2014
AU 2014230822 A1
BR 112015022617 A2
CA 2905571 A1
CN 105246910 A
CN 107029227 A
EP 2970393 A1
EP 3178840 A1
JP 6285469 B2
JP 2016510983 A
US 2014271696 A1
WO 2014140083 A1
01 October 2015
31 October 2017
18 September 2014
13 January 2016
11 August 2017
20 January 2016
14 June 2017
28 February 2018
14 April 2016
18 September 2014
18 September 2014
WO 2010149743 A2
29 December 2010
AU 2010264686 A1
CA 2766205 A1
CN 102548578 A
EA 201270062 A1
EP 2445527 A2
JP 5796011 B2
JP 2012530761 A
KR 20120093811 A
SG 176807 A1
US 2012135028 A1
WO 2010149743 A2
ZA 201109164 B
19 January 2012
29 December 2010
04 July 2012
28 February 2013
02 May 2012
21 October 2015
06 December 2012
23 August 2012
30 January 2012
31 May 2012
29 December 2010
26 September 2012
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
14 November 2018
Date of mailing of the international search report:
27 November 2018
Authorized officer:
Mossier, Birgit
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