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1. (WO2019043065) METHOD AND PREPARATION FOR SORTING OUT T EFFECTOR CELLS USING ANTI-CD127 ANTIBODIES FOR APPLICATIONS IN CELL THERAPY



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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/EP2018/073253 B12684A-AD/H
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
29 August 2018 29 August 2017
Applicant
OSE IMMUNOTHERAPEUTICS
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     C07K 16/28 (2006.01)i; C12N 5/00 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     C07K; C12N
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, BIOSIS, EMBASE, WPI Data

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X,P
WO 2017149394 A1 (OSE IMMUNOTHERAPEUTICS [FR]) 08 September 2017 (2017-09-08)
1-20
abstract, p. 3 line 5 - p. 10 line 13, p. 31 line 17 - p. 46 last line of the Table, claims
(2)
X
S. TOUIL ET AL, "Depletion of T regulatory cells through selection of CD127-positive cells results in a population enriched in memory T cells: implications for anti-tumor cell therapy", HAEMATOLOGICA, THE HEMATOLOGY JOURNAL : OFFICIAL ORGAN OF THE EUROPEAN HEMATOLOGY ASSOCIATION,Vol. 97, No. 11, 01 November 2012 (2012-11-01), page 1678-1685,
XP055419575
1-20
abstract, p. 1679 left-hand column second full paragraph - fourth full paragraph and right-hand column second and third full paragraphs, p. 1680 left-hand column first and second full paragraphs, right-hand column last full paragraph, paragraph bridging p. 1681 to p. 1682 - p. 1683 left-hand column first full paragraph, p. 1684 left-hand column first full paragraph - right-hand column first full paragraph and Fig. 1-4
(3)
X
NATALIA MAREK ET AL, "The Time Is Crucial for Ex Vivo Expansion of T Regulatory Cells for Therapy", CELL TRANSPLANTATION,Vol. 20, No. 11, 01 November 2011 (2011-11-01), page 1747-1758,
XP055083629
1-14,19,20
A
abstract, p. 1748 paragraph bridging the left- to the right-hand column - right-hand column first full paragraph, Fig. 1, 4, 5 and 6
15-18
(4)
A
VOLKER SCHIRRMACHER, "Cancer-reactive memory T cells from bone marrow: Spontaneous induction and therapeutic potential (Review)", INTERNATIONAL JOURNAL OF ONCOLOGY,Vol. 47, No. 6, 12 October 2015 (2015-10-12), page 2005-2016,
XP055434149
1-20
abstract, p. 2 paragraph bridging the left- to the right-hand column - p. 3 left-hand column line 6, p. 4 left-hand column first full paragraph - p. 6 left-hand column line 5, p. 7 right-hand column second full paragraph - p. 9 left-hand column first full paragraph
(5)
A
ROBERT F. KUDERNATSCH ET AL, "Human bone marrow contains a subset of quiescent early memory CD8 + T cells characterized by high CD127 expression and efflux capacity : Cellular immune response", EUROPEAN JOURNAL OF IMMUNOLOGY,Vol. 44, No. 12, 27 October 2014 (2014-10-27), page 3532-3542,
XP055434147
1-20
the whole document
(6)
A
LIU WEIHONG ET AL, "CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4(+) T reg cells", THE JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIVERSITY PRESS, US,Vol. 203, No. 7, 01 July 2006 (2006-07-01), page 1701-1711,
XP002469608
1-20
the whole document
(7)
A
EP 2583980 A1 (EFFIMUNE [FR]; INST NAT SANTE RECH MED [FR]) 24 April 2013 (2013-04-24)
1-20
abstract, claim 11;the whole document
(8)
A
NICOLAS A. GIRALDO ET AL, "Tumor-Infiltrating and Peripheral Blood T-cell Immunophenotypes Predict Early Relapse in Localized Clear Cell Renal Cell Carcinoma", CLINICAL CANCER RESEARCH,Vol. 23, No. 15, 01 August 2017 (2017-08-01), page 4416-4428,
XP055420162
1-20
the whole document
(9)
A
EP 2955196 A1 (EFFIMUNE [FR]) 16 December 2015 (2015-12-16)
1-20
the whole document
(10)
A
SANDER KELDERMAN ET AL, "Antigen-specific TIL therapy for melanoma: A flexible platform for personalized cancer immunotherapy", EUROPEAN JOURNAL OF IMMUNOLOGY,Vol. 46, No. 6, 03 May 2016 (2016-05-03), page 1351-1360,
XP055431343
1-20
the whole document
(11)
A
YOSR HICHERI ET AL, "Donor Regulatory T Cells Identified by FoxP3 Expression but Also by the Membranous CD4+CD127low/neg Phenotype Influence Graft-versus-tumor Effect After Donor Lymphocyte Infusion :", JOURNAL OF IMMUNOTHERAPY,Vol. 31, No. 9, 01 November 2008 (2008-11-01), page 806-811,
XP055508760
1-20
the whole document
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
WO 2017149394 A1
08 September 2017
AU 2017225495 A1
CA 3014313 A1
WO 2017149394 A1
23 August 2018
08 September 2017
08 September 2017
EP 2583980 A1
24 April 2013
EP 2583980 A1
EP 2768860 A1
EP 3299392 A1
JP 2014532074 A
JP 2017184753 A
US 2014308281 A1
WO 2013056984 A1
24 April 2013
27 August 2014
28 March 2018
04 December 2014
12 October 2017
16 October 2014
25 April 2013
EP 2955196 A1
16 December 2015
AU 2015273532 A1
BR 112016028755 A2
CA 2950823 A1
CL 2016003172 A1
CN 106715471 A
CR 20160576 A
EA 201692460 A1
EP 2955196 A1
EP 3155014 A1
HK 1231487 A1
JP 2017522903 A
KR 20170019417 A
PE 03242017 A1
PH 12016502445 A1
SG 11201610036P A
TN 2016000528 A1
US 2017129959 A1
WO 2015189302 A1
22 December 2016
14 November 2017
17 December 2015
14 July 2017
24 May 2017
08 May 2017
28 April 2017
16 December 2015
19 April 2017
22 December 2017
17 August 2017
21 February 2017
01 April 2017
06 March 2017
29 December 2016
04 April 2018
11 May 2017
17 December 2015
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
21 September 2018
Date of mailing of the international search report:
04 October 2018
Authorized officer:
Hermann, Patrice
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