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1. (WO2019030691) EXTRUDATE ENZALUTAMIDE COMPOSITIONS
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CLAIMS

1. An oral extrudate pharmaceutical composition comprising:

(i) 160 mg or 80 mg enzalutamide, and

(ii) one or more polymers.

2. The composition as claimed in claim 1 , wherein the amount of enzalutamide and polymer are present in a weight ratio from about 1 :0.5 to about 1 :5.

3. The composition as claimed in claim 1 , wherein the amount of enzalutamide and polymer are present in a weight ratio of 1 :0.7 to 1 :2.

4. The composition as claimed in claim 1 , wherein the polymer is selected from one or more of cellulosic polymer or non-cellulosic polymer or mixtures thereof.

5. The composition as claimed in claim 4, wherein the cellulosic polymer is selected from one or more of hydroxypropyl methyl cellulose acetate, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, methyl cellulose, hydroxyethyl methyl cellulose, hydroxyethyl cellulose acetate, hydroxyethyl ethyl cellulose, hydroxypropyl methyl cellulose acetate succinate, hydroxypropyl methyl cellulose succinate, hydroxypropyl cellulose acetate succinate, hydroxyethyl methyl cellulose succinate, hydroxyethyl cellulose acetate succinate, hydroxypropyl methyl cellulose phthalate, hydroxyethyl methyl cellulose acetate succinate, hydroxyethyl methyl cellulose acetate phthalate and any mixtures thereof.

6. The composition as claimed in claim 4, wherein the non-cellulosic polymers is selected from one or more of vinyl polymers and copolymers, polyvinyl alcohol polyvinyl acetate copolymers; polyvinyl pyrrolidone; polyvinylpyrrolidone vinyl acetate, polyethylene polyvinyl alcohol copolymers, carboxylic acid-functionalized vinyl polymers, copolymers of methacrylates and acrylates, graft copolymers of polyethylene glycol, polyvinylcaprolactam, and polyvinylacetate and any mixtures thereof.

7. The composition as claimed in claim 4, wherein the polymer is graft copolymers of polyethylene glycol, polyvinylcaprolactam, and polyvinylacetate.

8. The composition as claimed in claim 4, wherein the polymer is hydroxypropyl methyl cellulose acetate succinate.

9. The composition as claimed in claim 4, wherein the composition further comprising one or more pharmaceutically acceptable excipients.

10. An oral extrudate pharmaceutical composition comprising:

(i) 160 mg enzalutamide, and

(ii) one or more polymers selected from hydroxypropyl methyl cellulose acetate succinate, graft copolymers of polyethylene glycol, polyvinylcaprolactam and polyvinylacetate ,

wherein the amount of enzalutamide and polymer are present in a weight ratio of 1 :2 or 1 :1.