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1. (WO2017008773) CRYSTALLINE FORMS OF OBETICHOLIC ACID



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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/CZ2016/000078 PV/991/PCT
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
18 July 2016 16 July 2015
Applicant
ZENTIVA, K.S.
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     C07J 9/00 (2006.01)i; A61K 31/575 (2006.01)i; A61P 3/00 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     C07J; C07B; A61K; A61P
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, CHEM ABS Data, WPI Data

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
WO 2013192097 A1 (INTERCEPT PHARMACEUTICALS INC [US]) 27 December 2013 (2013-12-27)
1-16
page 32, paragraph 2
page 26, paragraph 3
page 63, paragraph 2; example 1
page 85, paragraph 1; example 6
page 88, paragraph 4; example 7
figures 5,6,36,40
(2)
X
WO 2014085474 A1 (INTERCEPT PHARMACEUTICALS INC [US]) 05 June 2014 (2014-06-05)
1-16
example 1
(3)
X,P
ZHOU, YUEGUANG ET AL, "Obeticholic acid crystal form I, its preparation method and the pharmaceutical composition", CAretrieved from STNDatabase accession no. 2015:2080440
Retrieved from the Internet:
URL:CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US
XP002762400
1-16
abstract
& CN 105175473  A  (LIVZON PHARMACEUTICAL GROUP) 23 December 2015 (2015-12-23)
(4)
DATABASE WPI Thomson Scientific, London, GB; Vol. 2016, No. 48, AN 2016-4143170
XP002762401
X,P
& WO 2016107575  A1  (CRYSTAL PHARMATECH CO LTD) 07 July 2016 (2016-07-07)
1-16
abstract
(5)
X,P
WO 2016079517 A1 (DEXTRA LAB LTD [GB]) 26 May 2016 (2016-05-26)
1-16
example 17
(6)
DATABASE WPI Thomson Scientific, London, GB; Vol. 2016, No. 46, AN 2016-28903L0
XP002762402
X,P
& CN 105541953  A  (CHENGDU XINGONG BIOTECHNOLOGY CO LTD) 04 May 2016 (2016-05-04)
1-16
abstract
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
WO 2013192097 A1
27 December 2013
AU 2013277429 A1
AU 2016200832 A1
CA 2877122 A1
CL 2015002145 A1
CN 104781272 A
CO 7240414 A2
EA 201590040 A1
EP 2861613 A1
HK 1211296 A1
JP 2015521621 A
JP 2016074724 A
KR 20150022974 A
NZ 703072 A
PH 12014502835 A1
SG 11201408501U A
TW 201410699 A
US 2013345188 A1
US 2016074419 A1
US 2016176913 A1
US 2016215014 A1
WO 2013192097 A1
22 January 2015
25 February 2016
27 December 2013
11 December 2015
15 July 2015
17 April 2015
29 May 2015
22 April 2015
20 May 2016
30 July 2015
12 May 2016
04 March 2015
24 June 2016
02 February 2015
29 January 2015
16 March 2014
26 December 2013
17 March 2016
23 June 2016
28 July 2016
27 December 2013
WO 2014085474 A1
05 June 2014
AU 2013352288 A1
CA 2891348 A1
CN 104853758 A
EP 2925328 A1
HK 1211844 A1
JP 2016500111 A
KR 20150089052 A
PH 12015501108 A1
SG 11201503697T A
TW 201434469 A
US 2014148428 A1
US 2016213689 A1
WO 2014085474 A1
04 June 2015
05 June 2014
19 August 2015
07 October 2015
03 June 2016
07 January 2016
04 August 2015
17 August 2015
29 June 2015
16 September 2014
29 May 2014
28 July 2016
05 June 2014
CN 105175473 A
23 December 2015
NONE
WO 2016107575 A1
07 July 2016
CN 105801653 A
WO 2016107575 A1
27 July 2016
07 July 2016
WO 2016079517 A1
26 May 2016
NONE
CN 105541953 A
04 May 2016
NONE
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
29 September 2016
Date of mailing of the international search report:
10 October 2016
Authorized officer:
Watchorn, Peter
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