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1. (WO2016112381) RESTORING PHYSIOLOGY IN IRON-DEFICIENT ORGANISMS USING SMALL MOLECULES

Pub. No.:    WO/2016/112381    International Application No.:    PCT/US2016/012855
Publication Date: 14.07.2016 International Filing Date: 11.01.2016
IPC: A61P 7/06
A61P 39/04
A61K 31/7048
Applicants: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
Inventors: BURKE, Martin, D.
GRILLO, Anthony, S.
Title: RESTORING PHYSIOLOGY IN IRON-DEFICIENT ORGANISMS USING SMALL MOLECULES
Abstract:
Provided are methods of treating a disease or condition characterized by a deficiency of or a defect in an iron transporter using a small molecule. For example, the method may increase transepithelial iron transport, or it may increase iron release. Additionally, the small molecule may be hinokitiol, or it may be selected from the group consisting of amphotericin B, calcimycin, nonactin, deferiprone, purpurogallin, and maltol. Also provided is a method of identifying a compound capable of treating a disease or condition characterized by a deficiency of or a defect in an iron transporter.