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1. (WO2016051424) A FORMULATION USEFUL FOR DELIVERY OF NEURO PROTECTING AGENT

Pub. No.:    WO/2016/051424    International Application No.:    PCT/IN2015/050124
Publication Date: Fri Apr 08 01:59:59 CEST 2016 International Filing Date: Wed Sep 30 01:59:59 CEST 2015
IPC: A61K 9/127
A61K 36/81
A61K 9/20
A61K 9/48
A61P 9/10
Applicants: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
Inventors: DWIVEDI, Anil Kumar
AHMAD, Hafsa
KHANDELWAL, Kiran
SANGWAN, Rajender Singh
SANGWAN, Neelam Singh
GAYEN, Jiaur Rahaman
., Sarika
BHADUARIA, Smrati
GAUR, Suresh Pratap Singh
BHOSALE, Vivek Vidyadhar
RATH, Srikanta Kumar
SHARMA, Sharad
SHUKLA, Rakesh
Title: A FORMULATION USEFUL FOR DELIVERY OF NEURO PROTECTING AGENT
Abstract:
The present invention relates to a formulation useful for delivery of neuro protecting agent. It also demonstrates and discloses a novel delivery system for an extract of a new chemotype of Withania sonmifera (NMITLI118RT+) for neuro- protection against cerebral stroke (signifies concentrated aqueous ethanolic extract of roots of NMITLI-118, a new chemotype of Withania somnifera, a variety of Ashwagandha, which is unique in having high root yield, possessing a uniform crop canopy and uniform composition with respect to its secondary metabolites- withanolides. It is phytochemically characterized by particular abundance of two withanolides i.e. withanone and/or withanolide A, specimens of which are kept in the herbarium of CSIR-CIMAP, Lucknow, India) (Chaurasiya ND, Sangwan RS, Mishra L N, Tuli R, Sangwan N S, Metabolic clustering of a core collection of Indian ginseng Withania somnifera Dunal through DNA, Isoenzyme, polypeptide and withanolide profile diversity-Fitoterapia 2009, 80 (8) 496-505) for neuro- protection against cerebral stroke. Broadly, the invention discloses potent and prudent therapeutic potential of a new formulation using standardized fraction NMITLI118RT+ of a new variety of Withania somnifera (Ashwagandha) for brain function restoration and protection from neurological failures. Particularly the present invention further relates to the process for the preparation of the said formulation containing Standardized NMITLI118RT+ extract, its pharmaceutical compositions, for the management of cerebral stroke. The present invention also relates to a method of treatment of cerebral stroke and comprising of administering the formulation in a predetermined doses and period.