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1. (WO2010003041) MITOTIC FIGURE DETECTOR AND COUNTER SYSTEM AND METHOD FOR DETECTING AND COUNTING MITOTIC FIGURES

Pub. No.:    WO/2010/003041    International Application No.:    PCT/US2009/049484
Publication Date: Fri Jan 08 00:59:59 CET 2010 International Filing Date: Fri Jul 03 01:59:59 CEST 2009
IPC: G06T 7/00
G06K 9/00
G06F 15/00
Applicants: NEC LABORATORIES AMERICA, INC.
Inventors: COSATTO, Eric
BURGER, Harold, Christopher
MILLER, Matthew, L.
Title: MITOTIC FIGURE DETECTOR AND COUNTER SYSTEM AND METHOD FOR DETECTING AND COUNTING MITOTIC FIGURES
Abstract:
A method and system for detecting and counting mitotic figures in an image of a biopsy sample stained with at least one dye, includes color filtering the image in a computer process to identify pixels in the image that have a color which is indicative a mitotic figure; extracting the mitotic pixels in the image that are connected to one another in a computer process, thereby producing blobs of mitotic pixels; shape-filtering and clustering the blobs of mitotic pixels in a computer process to produce mitotic figure candidates; extracting sub-images of mitotic figures by cropping the biopsy sample image at the location of the blobs; extracting two sets of features from the mitotic figure candidates in two separate computer processes; determining which of the mitotic figure candidates are mitotic figures in a computer classification process based on the extracted sets of features; and counting the number of mitotic figures per square unit of biopsy sample tissue.