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1. (WO1999035116) CERTAIN DITERPENES AND EXTRACTS OR CONCENTRATES OF CURCUMA AMADA CONTAINING THEM FOR USE AS MEDICAMENTS

Pub. No.:    WO/1999/035116    International Application No.:    PCT/DK1999/000008
Publication Date: Fri Jul 16 01:59:59 CEST 1999 International Filing Date: Sat Jan 09 00:59:59 CET 1999
IPC: C07C 33/14
C07C 45/78
C07C 47/225
C07C 47/267
Applicants: IDA DEVELOPMENT A/S
WEIDNER, Morten, Sloth
PETERSEN, Morten, Just
JENSEN, Nina, Worm
Inventors: WEIDNER, Morten, Sloth
PETERSEN, Morten, Just
JENSEN, Nina, Worm
Title: CERTAIN DITERPENES AND EXTRACTS OR CONCENTRATES OF CURCUMA AMADA CONTAINING THEM FOR USE AS MEDICAMENTS
Abstract:
Certain diterpenes as well as extracts or concentrates of the plant Curcuma amada containing at least one such diterpene can be used as medicaments for immunomodulation and for the alleviation of pain. Specifically, they are used for preparing medicaments for the treatment or prevention of hypersensitivity diseases, in particular IgE mediated allergic reactions and conditions as well as autoimmune disorders. Extracts of the plant can i.e. be obtained by extraction or by hydro, steam or vacuum distillation of fresh or dried Curcuma amada or parts thereof, preferably the rhizome. Extraction may be performed with water or with a number of different organic solvents, preferably water miscible solvents, or with mixtures thereof. After the primary distillation or extraction process a second step of processing, such as liquid-liquid extraction, column chromatography, steam distillation or vacuum distillation, can be employed to remove or to concentrate and possibly isolate any constituent of the extract.