1. WO2026166506 - CLASS OF PYRANOSE DERIVATIVES, PREPARATION METHOD THEREFOR, AND USE THEREOF

Номер публикации WO/2026/166506

Дата публикации 13.08.2026

№ международной заявки PCT/CN2026/077460

Дата международной подачи 06.02.2026

МПК

C07H 5/06 2006.1

C	ХИМИЯ; МЕТАЛЛУРГИЯ
07	Органическая химия
H	Сахара; производные сахаров; нуклеозиды; нуклеотиды; нуклеиновые кислоты
5	Соединения, содержащие сахаридные радикалы, в которых гетеросвязи с кислородом замещены на то же число гетеросвязей с атомами галогена, азота, серы, селена или теллура
04	азота
06	аминосахара

C07H 5/08 2006.1

C	ХИМИЯ; МЕТАЛЛУРГИЯ
07	Органическая химия
H	Сахара; производные сахаров; нуклеозиды; нуклеотиды; нуклеиновые кислоты
5	Соединения, содержащие сахаридные радикалы, в которых гетеросвязи с кислородом замещены на то же число гетеросвязей с атомами галогена, азота, серы, селена или теллура
08	серы, селена или теллура

A61K 31/7016 2006.1

A	УДОВЛЕТВОРЕНИЕ ЖИЗНЕННЫХ ПОТРЕБНОСТЕЙ ЧЕЛОВЕКА
61	Медицина и ветеринария; гигиена
K	Лекарства и медикаменты для терапевтических, стоматологических или гигиенических целей
31	Лекарственные препараты, содержащие органические активные ингредиенты
70	углеводы; сахара; их производные
7016	дисахариды, например лактоза, лактулоза

A61P 29/00 2006.1

A	УДОВЛЕТВОРЕНИЕ ЖИЗНЕННЫХ ПОТРЕБНОСТЕЙ ЧЕЛОВЕКА
61	Медицина и ветеринария; гигиена
P	Специфическая терапевтическая активность химических соединений или лекарственных препаратов
29	Анальгетики нецентрального действия, жаропонижающие или противовоспалительные средства, например противоревматические средства; нестероидные противовоспалительные средства (НПВС)

C07H 5/06 2006.1

C	ХИМИЯ; МЕТАЛЛУРГИЯ
07	Органическая химия
H	Сахара; производные сахаров; нуклеозиды; нуклеотиды; нуклеиновые кислоты
5	Соединения, содержащие сахаридные радикалы, в которых гетеросвязи с кислородом замещены на то же число гетеросвязей с атомами галогена, азота, серы, селена или теллура
04	азота
06	аминосахара

C07H 5/08 2006.1

C	ХИМИЯ; МЕТАЛЛУРГИЯ
07	Органическая химия
H	Сахара; производные сахаров; нуклеозиды; нуклеотиды; нуклеиновые кислоты
5	Соединения, содержащие сахаридные радикалы, в которых гетеросвязи с кислородом замещены на то же число гетеросвязей с атомами галогена, азота, серы, селена или теллура
08	серы, селена или теллура

A61K 31/7016 2006.1

A	УДОВЛЕТВОРЕНИЕ ЖИЗНЕННЫХ ПОТРЕБНОСТЕЙ ЧЕЛОВЕКА
61	Медицина и ветеринария; гигиена
K	Лекарства и медикаменты для терапевтических, стоматологических или гигиенических целей
31	Лекарственные препараты, содержащие органические активные ингредиенты
70	углеводы; сахара; их производные
7016	дисахариды, например лактоза, лактулоза

A61P 29/00 2006.1

A	УДОВЛЕТВОРЕНИЕ ЖИЗНЕННЫХ ПОТРЕБНОСТЕЙ ЧЕЛОВЕКА
61	Медицина и ветеринария; гигиена
P	Специфическая терапевтическая активность химических соединений или лекарственных препаратов
29	Анальгетики нецентрального действия, жаропонижающие или противовоспалительные средства, например противоревматические средства; нестероидные противовоспалительные средства (НПВС)

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CPC

A61K 31/70

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
70	Carbohydrates; Sugars; Derivatives thereof

A61K 31/7008

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
70	Carbohydrates; Sugars; Derivatives thereof
7008	Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine

A61K 31/7016

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
70	Carbohydrates; Sugars; Derivatives thereof
7016	Disaccharides, e.g. lactose, lactulose

A61K 31/7024

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
70	Carbohydrates; Sugars; Derivatives thereof
7024	Esters of saccharides

A61K 31/7028

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
70	Carbohydrates; Sugars; Derivatives thereof
7028	Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages

A61K 31/7032

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
70	Carbohydrates; Sugars; Derivatives thereof
7028	Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
7032	attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides

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A61K 31/70

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
70	Carbohydrates; Sugars; Derivatives thereof

A61K 31/7008

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
70	Carbohydrates; Sugars; Derivatives thereof
7008	Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine

A61K 31/7016

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
70	Carbohydrates; Sugars; Derivatives thereof
7016	Disaccharides, e.g. lactose, lactulose

A61K 31/7024

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
70	Carbohydrates; Sugars; Derivatives thereof
7024	Esters of saccharides

A61K 31/7028

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
70	Carbohydrates; Sugars; Derivatives thereof
7028	Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages

A61K 31/7032

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
70	Carbohydrates; Sugars; Derivatives thereof
7028	Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
7032	attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides

A61P 1/00

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1	Drugs for disorders of the alimentary tract or the digestive system

A61P 19/02

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19	Drugs for skeletal disorders
02	for joint disorders, e.g. arthritis, arthrosis

A61P 21/00

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21	Drugs for disorders of the muscular or neuromuscular system

A61P 25/00

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25	Drugs for disorders of the nervous system

A61P 25/16

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25	Drugs for disorders of the nervous system
14	for treating abnormal movements, e.g. chorea, dyskinesia
16	Anti-Parkinson drugs

A61P 25/18

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25	Drugs for disorders of the nervous system
18	Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

A61P 25/22

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25	Drugs for disorders of the nervous system
22	Anxiolytics

A61P 25/24

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25	Drugs for disorders of the nervous system
24	Antidepressants

A61P 25/28

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25	Drugs for disorders of the nervous system
28	for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

A61P 29/00

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29	Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)

A61P 37/06

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37	Drugs for immunological or allergic disorders
02	Immunomodulators
06	Immunosuppressants, e.g. drugs for graft rejection

A61P 7/06

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7	Drugs for disorders of the blood or the extracellular fluid
06	Antianaemics

A61P 9/00

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9	Drugs for disorders of the cardiovascular system

A61P 9/10

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9	Drugs for disorders of the cardiovascular system
10	for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

C07D 309/10

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
309	Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
02	having no double bonds between ring members or between ring members and non-ring members
08	with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
10	Oxygen atoms

C07H 1/00

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
H	SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1	Processes for the preparation of sugar derivatives

C07H 13/04

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
H	SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
13	Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
02	by carboxylic acids
04	having the esterifying carboxyl radicals attached to acyclic carbon atoms

C07H 13/06

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
H	SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
13	Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
02	by carboxylic acids
04	having the esterifying carboxyl radicals attached to acyclic carbon atoms
06	Fatty acids

C07H 15/04

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
H	SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15	Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
02	Acyclic radicals, not substituted by cyclic structures
04	attached to an oxygen atom of the saccharide radical

C07H 5/06

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
H	SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
5	Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
04	to nitrogen
06	Aminosugars

C07H 5/08

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
H	SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
5	Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
08	to sulfur, selenium or tellurium

C07H 5/10

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
H	SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
5	Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
08	to sulfur, selenium or tellurium
10	to sulfur

C07H 9/02

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
H	SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
9	Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
02	the hetero ring containing only oxygen as ring hetero atoms

C07H 9/04

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
H	SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
9	Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
02	the hetero ring containing only oxygen as ring hetero atoms
04	Cyclic acetals

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Заявители

• 旺山旺水（上海）生物医药有限公司 VIGONVITA (SHANGHAI) LIFE SCIENCES CO., LTD. [CN]/[CN]
• 中国科学院上海药物研究所 SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES [CN]/[CN]
• 中国科学院新疆理化技术研究所 XINJIANG TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY, CHINESE ACADEMY OF SCIENCES [CN]/[CN]

Изобретатели

• 艾萨·阿吉艾克拜尔 AISA, Haji Akber
• 张岩 ZHANG, Yan
• 侯琼琼 HOU, Qiongqiong
• 胡天文 HU, Tianwen
• 蒋翔锐 JIANG, Xiangrui
• 李志强 LI, Zhiqiang
• 黄书红 HUANG, Shuhong
• 郑伟 ZHENG, Wei
• 田广辉 TIAN, Guanghui
• 沈敬山 SHEN, Jingshan

Агенты

• 北京金信知识产权代理有限公司 KINGSOUND & PARTNERS

Дата приоритета

202510140168.0

08.02.2025

CN

Язык публикации Китайский (zh)

Язык подачи Китайский (zh)

Указанные государства

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AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CV, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IQ, IR, IS, IT, JM, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, MG, MK, MN, MU, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UY, UZ, VC, VN, WS, ZA, ZM, ZW
Африканская региональная организация интеллектуальной собственности (АРОИС) (BW, CV, GH, GM, KE, LR, LS, MU, MW, MZ, NA, RW, SC, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Евразийское патентное ведомство (ЕАПВ) (AM, AZ, BY, KG, KZ, RU, TJ, TM)
Европейское патентное ведомство (ЕПВ) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, ME, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
Африканская организация интеллектуальной собственности (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)

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Название

(EN) CLASS OF PYRANOSE DERIVATIVES, PREPARATION METHOD THEREFOR, AND USE THEREOF

(FR) CLASSE DE DÉRIVÉS DE PYRANOSE, PROCÉDÉ DE PRÉPARATION ET UTILISATION ASSOCIÉS

(ZH) 一类吡喃糖衍生物及其制备方法和用途

Реферат

(EN) Disclosed are a class of pyranose derivatives represented by the following general formula I, stereoisomers, pharmaceutically acceptable salts, crystalline hydrates, or solvates thereof, a preparation method therefor, a pharmaceutical composition comprising this class of compounds, and a use thereof in central nervous system diseases and inflammatory diseases. The pyranose derivatives of the present invention have efficacy in significantly improving cell viability in an Aβ1-42-induced cell injury model, improving cell viability in a 6-hydroxydopamine-induced cell injury model, improving cell viability in an oxygen-glucose deprivation/reoxygenation cell injury model, and inhibiting levels of inflammatory factors in a lipopolysaccharide-induced cell inflammation model, and thus have favorable prospects for clinical applications.

(FR) L'invention concerne une classe de dérivés de pyranose représentés par la formule générale I suivante, des stéréoisomères, des sels pharmaceutiquement acceptables, des hydrates cristallins ou des solvates de ceux-ci, un procédé de préparation associé, une composition pharmaceutique comprenant cette classe de composés, et leur utilisation dans des maladies du système nerveux central et des maladies inflammatoires. Les dérivés de pyranose selon la présente invention ont une efficacité dans l'amélioration significative de la viabilité cellulaire dans un modèle de lésion cellulaire induite par Aβ1-42, l'amélioration de la viabilité cellulaire dans un modèle de lésion cellulaire induite par 6-hydroxydopamine, l'amélioration de la viabilité cellulaire dans un modèle de lésion cellulaire de privation/réoxygénation de glucose-oxygène, et l'inhibition des niveaux de facteurs inflammatoires dans un modèle d'inflammation cellulaire induite par lipopolysaccharides, et présentent ainsi des perspectives favorables pour des applications cliniques.

(ZH) 本发明公开了一类下述通式I表示的吡喃糖衍生物、其立体异构体，药学上可接受的盐、结晶水合物或溶剂合物，其制备方法、包含该类化合物的药物组合物以及其在中枢神经系统疾病和炎症性疾病等方面的应用。根据本发明的吡喃糖类衍生物具有显著提升Aβ1-42诱导的细胞损伤模型细胞活力，提升6-羟基多巴胺诱导的细胞损伤模型细胞活力，提升氧糖剥夺/复氧细胞损伤模型细胞活力，抑制脂多糖诱导的细胞炎症因子水平等药效，具有良好的临床应用前景。

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