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1. (WO2014121077) METHOD FOR GENERATING RETINAL PIGMENT EPITHELIUM (RPE) CELLS FROM INDUCED PLURIPOTENT STEM CELLS (IPSCs)
Новейшие библиограф. данные, касающиеся досье в Международном бюро   

TranslationПеревести: оригинал-->русский
№ публикации:    WO/2014/121077    № международной заявки:    PCT/US2014/014160
Дата публикации: 07.08.2014 Дата международной подачи: 31.01.2014
МПК:
C12N 5/079 (2010.01), C12N 5/074 (2010.01)
Заявители: THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; National Institutes of Health Office of Technology Transfer 6011 Executive Boulevard Suite 325, MSC 7660 Bethesda, MD 20852-7660 (US)
Изобретатели: BHARTI, Kapil; (US).
DAVIS, Janine; (US).
MAMINISHKIS, Arvydas; (US).
FERRER-ALEGRE, Marc; (US).
MILLER, Sheldon, S.; (US)
Агент: SIEGEL, Susan, Alpert; Klarquist Sparkman, LLP One World Trade Center, Suite 1600 121 SW Salmon Street Portland, OR 97204 (US)
Дата приоритета:
61/759,988 01.02.2013 US
Название (EN) METHOD FOR GENERATING RETINAL PIGMENT EPITHELIUM (RPE) CELLS FROM INDUCED PLURIPOTENT STEM CELLS (IPSCs)
(FR) PROCÉDÉ DE GÉNÉRATION DE CELLULES ÉPITHÉLIALES PIGMENTAIRES RÉTINIENNES (EPR) À PARTIR DE CELLULES SOUCHES PLURIPOTENTES INDUITES (CSPI)
Реферат: front page image
(EN)High efficiency methods for producing retinal pigment epithelial cells from induced pluripotent stem cells (iPSCs) are disclosed herein. The iPSCs are produced from somatic cells, including retinal pigment epithelial (RPE) cells, such as fetal RPE stem cells. In some embodiments, the iPSC include a tyrosinase promoter operably linked to a marker. Methods are disclosed for using the RPE cells, such as for treatment. Methods for screening for agents that affect RPE differentiation are also disclosed.
(FR)La présente invention concerne des procédés très efficaces de production de cellules épithéliales pigmentaires rétiniennes à partir de cellules souches pluripotentes induites (CSPi). Les CSPi sont produites à partir de cellules somatiques et, notamment, de cellules épithéliales pigmentaires rétiniennes (EPR), telles que les cellules souches EPR fœtales. Selon certains modes de réalisation, les CSPi comprennent un promoteur de la tyrosinase en liaison fonctionnelle avec un marqueur. L'invention concerne également des procédés d'utilisation desdites cellules EPR, par exemple à des fins de traitement. L'invention concerne, en outre, des procédés de criblage permettant de rechercher des agents ayant une incidence sur la différentiation des cellules EPR.
Указанные государства: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Язык публикации: English (EN)
Язык подачи: English (EN)