Поиск по международным и национальным патентным фондам

1. (WO2016110593) COMBINED PREPARATIONS FOR THE TREATMENT OF CANCER OR INFECTION

Pub. No.:    WO/2016/110593    International Application No.:    PCT/EP2016/050321
Publication Date: Fri Jul 15 01:59:59 CEST 2016 International Filing Date: Sat Jan 09 00:59:59 CET 2016
IPC: A61K 38/17
A61K 39/395
A61P 35/00
A61P 31/00
Applicants: IMMUTEP S.A.S.
Inventors: TRIEBEL, Frédéric
BRIGNONE, Chrystelle
Title: COMBINED PREPARATIONS FOR THE TREATMENT OF CANCER OR INFECTION
Abstract:
Combined preparations, and pharmaceutical compositions, comprising: (a) LAG-3 protein, or a derivative thereof that is able to bind to MHC class II molecules; and (b) a programmed cell death protein-1 (PD-1) pathway inhibitor, are described. The PD-1 pathway inhibitor, such as an anti-PD-1 antibody or an anti-PD-L1 antibody, and a soluble derivative of LAG- 3, acting as an APC activator, together synergistically activate T cells (in particular, CD8+ T cells). Use of the combined preparations and compositions as medicaments, in particular for the treatment of cancer or infection, and to methods for the treatment of cancer or infection, is described.