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1. (WO2014165990) SYSTEM AND METHOD FOR IMAGING BIOMARKERS INDICATIVE OF CARDIAC THERMAL ABLATION LESIONS

Pub. No.:    WO/2014/165990    International Application No.:    PCT/CA2014/050355
Publication Date: Fri Oct 17 01:59:59 CEST 2014 International Filing Date: Wed Apr 09 01:59:59 CEST 2014
IPC: A61B 5/00
A61B 5/055
A61B 6/00
A61B 8/00
C12Q 1/00
G06F 19/00
A61B 18/04
Applicants: SUNNYBROOK RESEARCH INSTITUTE
Inventors: SWAMINATHAN, Venkat R.
CELIK, Haydar
WRIGHT, Graham A.
Title: SYSTEM AND METHOD FOR IMAGING BIOMARKERS INDICATIVE OF CARDIAC THERMAL ABLATION LESIONS
Abstract:
-19- SYSTEM AND METHOD FOR IMAGING BIOMARKERS INDICATIVE OF CARDIAC THERMAL ABLATION LESIONS ABSTRACT OF THE DISCLOSURE Described here are systems and methods for visualizing thermal ablation lesions by imaging specific chemical compounds that are created during thermal ablation procedures, such as cardiac ablation procedures. When a cardiac ablation procedure is performed, a central area of coagulative necrosis is created at the treatment site. This necrotic region is surrounded by layers of tissues with ultra-structural and electrophysiological changes. Two particular changes include the denaturation of proteins and the formation of ferric iron containing chemical compounds, such as methemoglobin and metmyoglobin. The formation of and distribution of such chemical compounds can be imaged with the appropriate systems and methods. Accordingly, these chemical compounds can be utilized as biomarkers that indicate the presence and physical characteristics of thermal ablation lesions. Imaging can be performed using magnetic resonance imaging, optical imaging, or photoacoustic imaging, as examples.