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1. (WO2008021133) OSMOTIC DELIVERY SYSTEMS AND PISTON ASSEMBLIES

Pub. No.:    WO/2008/021133    International Application No.:    PCT/US2007/017634
Publication Date: Fri Feb 22 00:59:59 CET 2008 International Filing Date: Thu Aug 09 01:59:59 CEST 2007
IPC: A61K 9/00
Applicants: INTARCIA THERAPEUTICS, INC.
ALESSI, Thomas, R.
DESJARDIN, Michael, A.
LAM, Stan
LAUTENBACH, Scott, D.
ZAMORA, Pauline, C.
Inventors: ALESSI, Thomas, R.
DESJARDIN, Michael, A.
LAM, Stan
LAUTENBACH, Scott, D.
ZAMORA, Pauline, C.
Title: OSMOTIC DELIVERY SYSTEMS AND PISTON ASSEMBLIES
Abstract:
An osmotic delivery system is disclosed for delivering an active agent formulation to a fluid environment. The osmotic delivery system typically comprises a reservoir having a lumen that contains the active agent formulation and an osmotic agent formulation and a piston assembly positioned in the lumen to isolate the active agent formulation from the osmotic agent formulation. The piston assembly typically comprises a body constructed and arranged for positioning in the lumen. The body is typically made of a polymeric material that is, for example, resistant to leaching in an organic solvent. In one embodiment, the body is a columnar body having a rim at a distal end thereof for engaging and sealing against a wall of the reservoir and the piston assembly further comprises a spring retained at the distal end of the columnar body for biasing the rim of the columnar body against the wall of the reservoir.