OMPI – Pesquisa nas coleções internacionais e nacionais de patentes

1.WO/2021/211792TREATMENT OF CORONAVIRUS INFECTIONS WITH AURANOFIN

WO - 21.10.2021

CIP A61K 31/7135 № do pedido PCT/US2021/027404 Requerente GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. Inventor KUMAR, Mukesh

The present disclosure provides methods for treating viral infections, in particular treating coronavirus infections in a subject with auranofin.

2.WO/2022/162012ANTIBODIES BROADLY TARGETING CORONAVIRUSES AND USES THEREOF

WO - 04.08.2022

CIP A61P 31/14 № do pedido PCT/EP2022/051776 Requerente ETH ZURICH Inventor SALLUSTO, Federica

The present invention relates to antibodies, and antigen binding fragments thereof, that bind to the spike (S) protein of coronaviruses. The antibodies, and antigen binding fragments thereof, broadly target coronaviruses, including different alpha- and betacoronaviruses. The invention also relates to nucleic acids that encode, and to cells that express such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies and antibody fragments in the treatment and diagnosis of coronavirus infection. Furthermore, a recombinant peptide, polypeptide or protein comprising the epitope, to which the antibodies bind to, is provided, which may be useful in vaccination.

3.WO/2023/064538COMPOSITIONS CONTAINING CORONAVIRUS PROTEINS AND EPITOPES

WO - 20.04.2023

CIP A61K 39/215 № do pedido PCT/US2022/046682 Requerente LA JOLLA INSTITUTE FOR IMMUNOLOGY Inventor SHRESTA, Sujan

The present application relates to compositions of matter, processes and uses of compositions of matter relating to Coronavirus proteins, peptides and epitopes, for example, for therapeutic or preventative vaccination against one or more Coronavirus species, subspecies, or strains, and/or for inducing, enhancing, or sustaining an immune response against at least one Coronavirus serotype or species. The Coronavirus may be, for example, SARS-CoV-2, SARS-COV, MERS-COV, OC43, or any coronavirus, including the betacoronaviruses.

4.WO/2021/207213METHODS TO PREVENT SARS-COV-2 INFECTION AND TREAT COVID-19

WO - 14.10.2021

CIP C07K 16/10 № do pedido PCT/US2021/025980 Requerente UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED Inventor OSTROV, David A.

Methods of preventing or treating infection by a SARS-CoV-related betacoronavirus are described. The methods include administering to a patient at risk of being infected by a SARS-CoV-related betacoronavirus or suffering from SARS-CoV-related betacoronavirus-related illness a small molecule drug and/or an antibody that binds to the ACE2-SARS interaction domain of either ACE2 or SARS-CoV-2 spike protein. Also described are vaccines comprising S-protein polypeptides corresponding to the ACE-2 interaction domain.

5.WO/2024/082067MULTABODY CONSTRUCTS, COMPOSITIONS, AND METHODS TARGETING SARBECOVIRUSES

WO - 25.04.2024

CIP C07K 19/00 № do pedido PCT/CA2023/051399 Requerente THE HOSPITAL FOR SICK CHILDREN Inventor JULIEN, Jean-Philippe

Described herein is a fusion polypeptide comprising a sarbecovirus binding moiety linked to a nanocage monomer or subunit thereof, wherein the sarbecovirus binding moiety is capable of binding to SARS-CoV-2 and at least one sarbecovirus other than SARS-CoV-2. Also described are methods for treating and/or preventing sarbecovirus infection and/or a sarbecovirus-associated condition.

6.3173187METHODS FOR TREATMENT OF CORONAVIRUS INFECTIONS

CA - 14.10.2021

CIP A61K 31/195 № do pedido 3173187 Requerente UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. Inventor TRIPP, RALPH A.

Compositions and methods of treating a subject for a coronavirus infection are provided. The methods typically include administering the subject an effective amount of probenecid, a metabolite or analog thereof, or a pharmaceutically acceptable salt thereof. The methods can be therapeutic and/or prophylactic. The amount of probenecid, metabolite or analog thereof, or pharmaceutically acceptable salt thereof can be effective to, for example, reduce viral replication, reduce one or more symptoms of disease, disorder, or illness associated with virus, or a combination thereof. In preferred embodiments, the virus is a Severe acute respiratory syndrome-related coronavirus such as SARS-CoV-2 or SARS-CoV, a Middle East respiratory syndrome-related coronavirus such as MERS-CoV, or a coronavirus that causes the common cold.

7.WO/2021/163456T CELL EPITOPES AND RELATED COMPOSITIONS USEFUL IN THE PREVENTION, DIAGNOSIS, AND TREATMENT OF COVID-19

WO - 19.08.2021

CIP A61K 39/215 № do pedido PCT/US2021/017825 Requerente EPIVAX, INC. Inventor DE GROOT, Anne

The present disclosure generally relates to novel epitope-based compositions, including vaccines, against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and diseases caused by SARS-CoV-2, including the highly contagious coronavirus disease 2019 (which has been termed and may be referred to herein as "COVID-19", "2019-nCoV", or the "2019 novel coronavirus". The disclosure relates to immunogenic polypeptides and the uses thereof, particularly in vaccine compositions. The disclosure also relates to nucleic acids, vectors, and cells which express the polypeptides and the uses thereof. The polypeptides more specifically comprise an agretope predicted to be a ligand of HLA class I and/or HLA class II MHC molecules, as well as an epitope that is predicted to be recognized by T-cells in the context of MHC class I and/or class II molecules. The compositions are particularly suited to produce vaccines, particularly for vaccinating against SARS-CoV-2 infection and related diseases caused by SARS-CoV-2, including COVID-19.

8.3167493T CELL EPITOPES AND RELATED COMPOSITIONS USEFUL IN THE PREVENTION, DIAGNOSIS, AND TREATMENT OF COVID-19

CA - 19.08.2021

CIP A61K 39/215 № do pedido 3167493 Requerente EPIVAX, INC. Inventor DE GROOT, ANNE

9.WO/2023/030476IMMUNOGENIC COMPOSITIONS AND METHODS FOR IMMUNIZATION AGAINST VARIANTS OF SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2)

WO - 09.03.2023

CIP C07K 14/165 № do pedido PCT/CN2022/116668 Requerente MEDIGEN VACCINE BIOLOGICS CORPORATION Inventor CHEN, Charles

Provided are immunogenic compositions and methods for immunization against variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), especially an immunogenic composition having a recombinant SARS-CoV-2 S protein derived from Beta (B. 1.351) variant and methods using an immunogenic composition derived from SARS-CoV-2 Beta (B. 1.351) variant.

10.WO/2023/088968UNIVERSAL SARBECOVIRUS VACCINES

WO - 25.05.2023

CIP C07K 16/28 № do pedido PCT/EP2022/082134 Requerente INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) Inventor LEVY, Yves

Sarbecoviruses (lineage B of genus Betacoronavirus) have caused two major outbreaks during the past two decades: SARS-CoV in 2003, and SARS-CoV-2 from 2019. SARS-CoV-2 vaccines will be essential to reduce morbidity and mortality. Therefore, universal vaccines against this class of viruses are key to ending the current pandemic, but also for preventing additional emergent variations and future outbreaks of SARS-like viruses that are continuously found from nature reservoirs. Now, the inventors produced an antibody that is directed against a surface antigen (i.e., CD40) of an antigen presenting cell (i.e., dendritic cell) wherein the heavy chain is conjugated or fused to a protein N polypeptide of SAR-CoV-2 and the light chain is fused to a RBD polypeptide. In particular, the inventors show that said antibody could elicit immune responses against Sarbecoviruses.

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