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1. (WO2019046233) A METHOD TO MONITOR PHARMACODYNAMIC RESPONSES MEDIATED BY IN VIVO ADMINISTRATION OF GLUCOCORTICOIDS
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№ de pub.: WO/2019/046233 № do pedido internacional: PCT/US2018/048240
Data de publicação: 07.03.2019 Data de depósito internacional: 28.08.2018
CIP:
C12Q 1/6883 (2018.01)
[IPC code unknown for C12Q 1/6883]
Requerentes:
BRISTOL-MYERS SQUIBB COMPANY [US/US]; Route 206 and Province Line Road Princeton, New Jersey 08543, US
Inventores:
CARMAN, Julie; US
HU, Yanhua; US
Mandatário:
PARLET, Nickki L.; US
BELLOMY, Gregory R.; US
CHAO, Yuan; US
CLAUSS, Isabelle M.; US
COULTER, Kathryn; US
DELAUNEY, Ashton J.; US
EPPERSON, James; US
FARQUHARSON-TORRES, Serena; US
GOLIAN, Paul D.; US
GREENBLATT, Gary D.; US
GUO, Z. Angela; US
HADAD, Henry; US
HAN, Bo; US
HAI, Bing; US
JACOBSEN, Barry H.; US
KORSEN, Elliott; US
LAUB, Friedrich; US
LIU, Hong; US
MINGO, Pamela A.; US
SUN, Jing G.; US
VANATTEN, Mary K.; US
VOM WEGE, Julia; US
WALSH, Brian J.; US
Dados da prioridade:
62/551,83930.08.2017US
Título (EN) A METHOD TO MONITOR PHARMACODYNAMIC RESPONSES MEDIATED BY IN VIVO ADMINISTRATION OF GLUCOCORTICOIDS
(FR) PROCÉDÉ DE SURVEILLANCE DE RÉPONSES PHARMACODYNAMIQUES MÉDIÉES PAR L'ADMINISTRATION IN VIVO DE GLUCOCORTICOÏDES
Resumo:
(EN) The present invention relates generally to a method of monitoring pharmacodynamic responses mediated by in vivo administration of glucocorticoids. More specifically, the present invention relates to a method of using a change in gene signature as a pharmacodynamic marker of glucocorticoid exposure.
(FR) La présente invention concerne de manière générale un procédé de surveillance de réponses pharmacodynamiques médiées par l'administration in vivo de glucocorticoïdes. La présente invention concerne plus particulièrement un procédé d'utilisation d'un changement de signature génique en tant que marqueur pharmacodynamique d'exposition aux glucocorticoïdes.
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Estados designados: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
Organização Regional Africana da Propriedade Intelectual (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Instituto Eurasiático de Patentes (AM, AZ, BY, KG, KZ, RU, TJ, TM)
Instituto Europeu de Patentes (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
Organização Africana da Propriedade Intelectual (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Língua de publicação: inglês (EN)
Língua de depósito: inglês (EN)