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1. (WO2019028166) HYDROGEL BEADS FOR NUCLEOTIDE SEQUENCING



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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/US2018/044855 ILLINC392WO2
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
01 August 2018 01 August 2017
Applicant
ILLUMINA, INC.
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
1. With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
a. forming part of the international application as filed:
in the form of an Annex C/ST.25 text file.
on paper or in the form of an image file.
b. furnished together with the international application under PCT Rule 13ter.1(a) for the purposes of international search only in the form of an Annex C/ST.25 text file.
c. furnished subsequent to the international filing date for the purposes of international search only:
in the form of an Annex C/ST.25 text file (Rule 13ter.1(a)).
on paper or in the form of an image file (Rule 13ter.1(b) and Administrative Instructions, Section 713).
2.
In addition, in the case that more than one version or copy of a sequence listing has been filed or furnished, the required statements that the information in the subsequent or additional copies is identical to that forming part of the application as filed or does not go beyond the application as filed, as appropriate, were furnished.
3.
Additional comments:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No.     1    
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     C12Q 1/6806 (2018.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     C12Q
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, BIOSIS, EMBASE, WPI Data

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
RICHARD NOVAK1 ET AL, "Single-cell multiplex gene detection and sequencing with microfluidically generated agarose emulsions", 10 January 2011 (2011-01-10), Vol. 50, No. 2, page 390-395,
XP002629259
[retrieved on  2010-12-03]
1-3,5-13,15-23,25-30
Y
page 391, column 2, paragraph 2 - page 392, column 2, paragraph 2; figures 1,2
4,14,24,31-39
pages 392-394; figure 4
(2)
X
US 2015376609 A1 (HINDSON BENJAMIN [US] ET AL) 31 December 2015 (2015-12-31)
1-30
Y
paragraphs [0052], [0053], [0058], [0063] - [0070], [0089] - [0093], [0122], [0144]; figures 1,2,6
31-39
(3)
X
WO 2014145555 A1 (LARIAT BIOSCIENCES INC [US]) 18 September 2014 (2014-09-18)
1-3,5-13,15-23,25,26,28-30
Y
page 14, lines 12-25; page 29, lines 17-24; page 34, lines 10-24; page 36, lines 11-15; page 40, lines 22-33; page 41, line 18 - page 42, line 3;page 45, lines 3-21; page 58, line 24 - page 61, line 22;figures 16,17
4,14,24
(4)
X
WO 2015088299 A1 (UNIV VILNIUS [LT]) 18 June 2015 (2015-06-18)
1-3,5-13,15-18,20-23,25-28,30
Y
page 3 - page 4
4,14,24
page 7, lines 28-33
page 8, lines 24-26
page 13, lines 20-24; claim 16
(5)
X
KUMACHEV A ET AL, "High-throughput generation of hydrogel microbeads with varying elasticity for cell encapsulation", 01 February 2011 (2011-02-01), Vol. 32, No. 6, page 1477-1483,
XP027568265
[retrieved on  2010-12-21]
1-3,5-7,11-13,15-17,21-23,25-27
page 1478, column 1, paragraph 3 - page 1479, column 1, paragraph 3; figures 1,7
page 1481, column 2, paragraph 2
(6)
X
DANIEL C. PREGIBON ET AL, "Optimization of Encoded Hydrogel Particles for Nucleic Acid Quantification", ANALYTICAL CHEMISTRY,Vol. 81, No. 12, 15 June 2009 (2009-06-15), page 4873-4881,
XP055070969
1-3,5,10
page 4874, column 2, last paragraph - page 4875, column 1, paragraph 1; figure 1
page 4875, column 2, paragraph 3
(7)
Y
SIMONE PICELLI ET AL, "Tn5 transposase and tagmentation procedures for massively scaled sequencing projects", GENOME RESEARCH,Vol. 24, No. 12, 30 July 2014 (2014-07-30), page 2033-2040,
XP055236186
31-39
the whole document
(8)
X,P
WO 2018119301 A1 (UNIV CALIFORNIA [US]) 28 June 2018 (2018-06-28)
1-39
the whole document
paragraphs [0053] - [0061], [0075], [0135], [0134] - [0151]; figures 1-3
(9)
E
WO 2018140966 A1 (10X GENOMICS INC [US]) 02 August 2018 (2018-08-02)
1-30
paragraphs [0130] - [0141], [0149], [0150], [0158] - [0163], [0197] - [0203], [0330] - [0331], [0337]; figures 1,2,7
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
US 2015376609 A1
31 December 2015
AU 2015279548 A1
CA 2953374 A1
CN 106795553 A
EP 3161160 A2
JP 2017522867 A
KR 20170020704 A
US 2015376609 A1
WO 2015200893 A2
12 January 2017
30 December 2015
31 May 2017
03 May 2017
17 August 2017
23 February 2017
31 December 2015
30 December 2015
WO 2014145555 A1
18 September 2014
CA 2942908 A1
EP 2971136 A1
JP 2016517281 A
US 2016136643 A1
WO 2014145555 A1
18 September 2014
20 January 2016
16 June 2016
19 May 2016
18 September 2014
WO 2015088299 A1
18 June 2015
NONE
WO 2018119301 A1
28 June 2018
NONE
WO 2018140966 A1
02 August 2018
NONE
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
27 September 2018
Date of mailing of the international search report:
15 October 2018
Authorized officer:
Schmitt, Anja
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