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1. (WO2018220444) COMPOSITIONS AND METHODS FOR TREATING DRY EYE SYNDROME DELIVERING ANTIBIOTIC MACROLIDE
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CLAIMS:

What is claimed is:

1. A method of treating dry eye syndrome, comprising:

administering a composition to an eye of a mammal in need thereof;

wherein the composition is a sustained release composition;

wherein the composition is configured to release an effective amount of an active agent per day for a treatment period of at least seven days; and

wherein the active agent is Tacrolimus.

2. The method of claim 1, wherein the effective amount of the active agent measures 0.5-10 micrograms.

3. The method of claim 1, wherein the effective amount of the active agent measures between 0-60% by weight (w/w).

4. The method of claim 1, wherein the effective amount of the active agent measures between 5-40% by weight (w/w).

5. The method of claim 1, wherein the effective amount of the active agent measures between

5-20% by weight (w/w).

6. The method of claim 1, wherein the effective amount of the active agent measures between

10-20% by weight (w/w).

7. The method of claim 1, wherein the effective amount of the active agent measures between

10-17% by weight (w/w).

8. The method of claim 1, wherein the effective amount of the active agent measures between

10-15% by weight (w/w).

9. The method of claim 1, wherein the effective amount of the active agent measures between 10-13% by weight (w/w).

10. The method of claim 1, wherein the effective amount of the active agent measures between 13-20% by weight (w/w).

11. The method of claim 1, wherein the effective amount of the active agent measures between 15-20% by weight (w/w).

12. The method of claim 1, wherein the treatment period measures at least 14 days.

13. The method of claim 1, wherein the treatment period measures at least 21 days.

14. The method of claim 1, wherein the treatment period measures at least 30 days.

15. The method of claim 1, wherein the treatment period measures at least 60 days.

16. The method of claim 1, wherein the treatment period measures at least 90 days.

17. The method of claim 1, wherein the treatment period of release measures between 7-90 days.

18. The method of claim 1, wherein the composition is in a shape of a form selected from the group consisting of a cylinder, plug, coin, disk, plate, cube, sphere, fiber, box, diamond, ring, "S", "L", "T", web, net, mesh, "U", and "V".

19. The method of claim 1, wherein the composition is in a shape of a form comprising a cylinder, plug, coin, disk, plate, cube, sphere, fiber, box, diamond, ring, "S", "L", "T", web, net, mesh, "U", or "V".

20. A composition, comprising:

a bulking agent comprising a kaolin,

an absorbent material comprising a fumed silica,

a binder comprising an epoxy, and

an active agent comprising Tacrolimus.

21. The composition of claim 20, wherein the composition is in a shape of a form selected from the group consisting of a cylinder, plug, coin, disk, plate, cube, sphere, fiber, box, diamond, ring, "S", "L", "T", web, net, mesh, "U", and "V".

22. The composition of claim 20, wherein the composition is in a shape of a form comprising a cylinder, plug, coin, disk, plate, cube, sphere, fiber, box, diamond, ring, "S", "L", "T", web, net, mesh, "U", or "V".

23. A composition, comprising:

an absorbent material comprising a fumed silica,

a binder comprising an epoxy, and

an active agent comprising Tacrolimus.

24. The composition of claim 23, wherein the composition is in a shape of a form selected from the group consisting of a cylinder, plug, coin, disk, plate, cube, sphere, fiber, box, diamond, ring, "S", "L", "T", web, net, mesh, "U", and "V".

25. The composition of claim 23, wherein the composition is in a shape of a form comprising a cylinder, plug, coin, disk, plate, cube, sphere, fiber, box, diamond, ring, "S", "L", "T", web, net, mesh, "U", or "V".