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1. (WO2018039318) BIODEGRADABLE POLYMER FORMULATIONS FOR EXTENDED EFFICACY OF BOTULINUM TOXIN



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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/US2017/048174 AKIN 100 PCT
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
23 August 2017 26 August 2016
Applicant
AKINA, INC
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     A61K 9/14 (2006.01)i; A61K 38/48 (2006.01)i; A61K 9/16 (2006.01)i; A61K 9/00 (2006.01)i; A61K 47/34 (2017.01)i; A61K 47/36 (2006.01)i; A61K 9/113 (2006.01)n
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     A61K
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, WPI Data, BIOSIS, EMBASE

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
US 2010310669 A1 (PAILLARD ALEXANDRA [FR] ET AL) 09 December 2010 (2010-12-09)
1-6,9-18,24-36,46,50,51
Y
the whole document
7,8,37-44
paragraphs [0026], [0099], [0101], [0116]
(2)
X
JIANJUN WANG ET AL, "Stabilization and encapsulation of human immunoglobulin G into biodegradable microspheres", JOURNAL OF COLLOID AND INTERFACE SCIENCE,Vol. 271, No. 1, March 2004 (2004-03), page 92-101,
XP055092590
1-6,9-18,24-36,46,50,51
Y
page 93
7,8,37-44
page 96, right-hand column
page 98, right-hand column, paragraph 1
page 99, left-hand column, last paragraph
(3)
X
US 6312708 B1 (DONOVAN STEPHEN [US]) 06 November 2001 (2001-11-06)
1-6,9-36,45,47,49-51
cited in the application
Y
column 8, line 22 - line 44
7,8,37-44,48
column 22, line 9 - line 65
example 1
column 14, line 30 - line 34
column 18, line 38 - line 39
(4)
Y
LU YING ET AL, "Microparticles produced by the hydrogel template method for sustained drug delivery", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER, AMSTERDAM, NL,Vol. 461, No. 1, 11 December 2013 (2013-12-11), page 258-269,
XP028810400
7,8
cited in the application
the whole document
(5)
Y
US 2016175410 A1 (HUNT TERRENCE J [US]) 23 June 2016 (2016-06-23)
37-44,48
the whole document
(6)
A
YE M ET AL, "Issues in long-term protein delivery using biodegradable microparticles", September 2010 (2010-09), Vol. 146, No. 2, page 241-260,
XP027194174
[retrieved on  2010-05-19]
1-51
cited in the application
the whole document
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
US 2010310669 A1
09 December 2010
CA 2701377 A1
EP 2044934 A1
EP 2203159 A1
JP 5487511 B2
JP 2010540589 A
US 2010310669 A1
WO 2009043874 A1
09 April 2009
08 April 2009
07 July 2010
07 May 2014
24 December 2010
09 December 2010
09 April 2009
US 6312708 B1
06 November 2001
AR 028669 A1
AT 322251 T
AU 6504301 A
AU 7292701 A
BR 0111300 A
CA 2411277 A1
CN 1446081 A
DE 60118550 T2
EP 1289504 A2
EP 1655023 A1
ES 2259665 T3
JP 2003535117 A
JP 2012067144 A
KR 20030066330 A
NZ 522611 A
TW I250020 B
US 6306423 B1
US 6312708 B1
US 2002028216 A1
US 2002028244 A1
US 2002098237 A1
WO 0193827 A2
WO 0193890 A2
21 May 2003
15 April 2006
17 December 2001
17 December 2001
10 June 2003
13 December 2001
01 October 2003
08 February 2007
12 March 2003
10 May 2006
16 October 2006
25 November 2003
05 April 2012
09 August 2003
30 July 2004
01 March 2006
23 October 2001
06 November 2001
07 March 2002
07 March 2002
25 July 2002
13 December 2001
13 December 2001
US 2016175410 A1
23 June 2016
AU 2009215664 A1
CA 2715626 A1
CN 102014951 A
EP 2257304 A1
KR 20100135237 A
RU 2010138700 A
US 2009214685 A1
US 2015352226 A1
US 2016175410 A1
WO 2009105369 A1
27 August 2009
27 August 2009
13 April 2011
08 December 2010
24 December 2010
27 March 2012
27 August 2009
10 December 2015
23 June 2016
27 August 2009
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
20 November 2017
Date of mailing of the international search report:
11 December 2017
Authorized officer:
Palma, Vera
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