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1. (WO2018025596) METHOD FOR PREPARING THERAPEUTIC AGENT

Pub. No.:    WO/2018/025596    International Application No.:    PCT/JP2017/025279
Publication Date: Fri Feb 09 00:59:59 CET 2018 International Filing Date: Wed Jul 12 01:59:59 CEST 2017
IPC: A61K 35/12
A61K 35/28
A61P 1/16
A61P 9/10
A61P 13/12
C12N 5/077
Applicants: YAMAGUCHI UNIVERSITY
国立大学法人山口大学
SHIBUYA CORPORATION
澁谷工業株式会社
Inventors: SAKAIDA Isao
坂井田 功
TAKAMI Taro
高見 太郎
YONEDA Kenji
米田 健二
Title: METHOD FOR PREPARING THERAPEUTIC AGENT
Abstract:
In an operating room 8, about 40 mL of the bone marrow fluid 10 of a patient is sampled and housed in a collection tube 11. Then, the collection tube 11 is conveyed into an isolator 2 in a sterile state. In the isolator 2, the bone marrow fluid 10 in the collection tube 11 is pipetted into test tubes 13, culture tubes 14, etc. To the bone marrow fluid 10 in the culture tubes 14, an erythrocyte sedimentation agent is added. After thus precipitating erythrocytes, the supernatant is collected. From the collected supernatant, a bone marrow cell-containing fraction for liver regeneration is concentrated. The obtained concentrate is pipetted into flasks 5 (culture containers). Then, the flasks 5 are conveyed into an incubator 4 to start cell incubation. From the isolator 1, test tubes 13 and 16 are taken out. The bone marrow fluid 10 in the test tubes 13 and 16 and the concentrate are subjected to a safety inspection, etc. Thus, the safety of the bone marrow fluid 10 sampled from the patient can be inspected immediately after starting the incubation.