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1. (WO2015157704) METHODS AND COMPOSITIONS FOR DETECTING MISFOLDED PROTEINS
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№ de pub.: WO/2015/157704 № do pedido internacional: PCT/US2015/025432
Data de publicação: 15.10.2015 Data de depósito internacional: 10.04.2015
CIP:
G01N 33/52 (2006.01) ,G01N 33/68 (2006.01)
[IPC code unknown for G01N 33/52][IPC code unknown for G01N 33/68]
Requerentes:
YALE UNIVERSITY [US/US]; Two Whitney Avenue New Haven, CT 06511, US
Inventores:
BUHIMSCHI, Irina; US
BUHIMSCHI, Catalin, S.; US
CHOMA, Michael; US
TAGARE, Hemant; US
JONAS, Stephan, Michael; DE
Mandatário:
DIPIETRANTONIO, Heather, J.; US
Dados da prioridade:
61/978,15810.04.2014US
Título (EN) METHODS AND COMPOSITIONS FOR DETECTING MISFOLDED PROTEINS
(FR) PROCÉDÉS ET COMPOSITIONS DE DÉTECTION DE PROTÉINES MAL REPLIÉES
Resumo:
(EN) Various aspects and embodiments of the present disclosure are directed to methods and compositions (e.g., kits) for the identification of subjects with misfolded proteins in their urine. For example, methods and compositions for determining that a urine sample from a pregnant woman contains or does not contain misfolded are provided. In some embodiments, the presence of misfolded proteins in a urine sample from a pregnant woman is an indication of preeclampsia.
(FR) Divers aspects et modes de réalisation de la présente invention concernent des procédés et des compositions (par exemple, des kits) pour l'identification de sujets ayant des protéines mal repliées dans leur urine. L'invention concerne, par exemple, des procédés et compositions permettant de déterminer qu'un échantillon d'urine d'une femme enceinte contient ou ne contient pas de protéines mal repliées. Dans certains modes de réalisation, la présence de protéines mal repliées dans un échantillon d'urine d'une femme enceinte est une indication de pré-éclampsie.
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Estados designados: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
Organização Regional Africana da Propriedade Intelectual (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Instituto Eurasiático de Patentes (AM, AZ, BY, KG, KZ, RU, TJ, TM)
Instituto Europeu de Patentes (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
Organização Africana da Propriedade Intelectual (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Língua de publicação: inglês (EN)
Língua de depósito: inglês (EN)