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1. (WO2015119923) COMBINATION OF A PD-1 ANTAGONIST AND A 4-ABB AGONIST FOR TREATING CANCER

Pub. No.:    WO/2015/119923    International Application No.:    PCT/US2015/014199
Publication Date: Fri Aug 14 01:59:59 CEST 2015 International Filing Date: Wed Feb 04 00:59:59 CET 2015
IPC: C07K 16/28
A61P 35/00
A61K 39/35
Applicants: PFIZER INC.
MERCK SHARP& DOHME CORP.
Inventors: DAVIS, Craig, Bennett
KOEHLER, Maria, Theresa
YAN, Li
Title: COMBINATION OF A PD-1 ANTAGONIST AND A 4-ABB AGONIST FOR TREATING CANCER
Abstract:
The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor (PD-1) and a selective 4-1 BB agonist, and the use of the combination therapies for the treatment of cancer, and in particular for treating cancers that express PD-Ll.