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1. (WO2014090710) BENZYL SULFONAMIDE DERIVATIVES AS RORc MODULATORS
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CLAIMS

1. A compound of formula la or lb:


or a pharmaceutically acceptable salt thereof,

wherein:

m is 0 or 1 ;

n is 0 or 1 ;

r is from 0 to 3 ;

A is: a bond; -CH2-; -NRa-; or -0-;

one or two of X1, X2, X3 and X4 is N and the others are CRb; or three of X1, X2, X3 and X4 are N and the other is CRb; or each of X1, X2, X3 and X4 is CRb;

R1, R2, R3 and R4 each independently is: hydrogen; or C1-6alkyl which may be unsubstituted or substituted one or more times with halo;

R5 is: C1-6alkyl; C3-6cycloalkyl; C3-6cycloalkyl-C1-6alkyl; C1-6alkoxy-C1-6alkyl; or hydroxy-C1-6alkyl, wherein the C1-6alkyl, C3_6cycloalkyl and C3_6cycloalkyl-Ci_6alkyl moities may be substituted one or more times with halo;

each R6 is independently: C1-6alkyl; halo; Ci-6alkoxy; or cyano; wherein the C1-6alkyl moieties may be unsubstituted or substituted one or more times with halo;

R is: C1-6alkylsulfonyl; C3-6cycloalkylsulfonyl; C3-6cycloalkyl-C1-6alkylsulfonyl; aminosulfonyl; Ci_6alkylsulfonylamino; C1-6alkylcarbonyl; C3-6cycloalkylcarbonyl; C3_

6cycloalkyl-Ci_6alkylcarbonyl; or aminocarbonyl, wherein the Ci-6alkyl, C3_6cycloalkyl and C3_ 6cycloalkyl-Ci_6alkyl moieties may be unsubstituted or substituted one or more times with halo;

Q

R is: hydrogen; Ci-6alkyl; halo; Ci-6alkoxy; or cyano; wherein the Ci-6alkyl moieties may be unsubstituted or substituted one or more times with halo;

Ra is: hydrogen; or Ci-6alkyl which may be unsubstituted or substituted one or more times with halo; and

Each Rb is independently: hydrogen; Ci-6alkyl; halo; Ci-6alkoxy; or cyano; wherein the Ci_6alkyl moieties may be unsubstituted or substituted one or more times with halo.

2. The compound of claim 1, wherein m is 0.

3. The compound of claim 1 or 2, wherein n is 0.

4. The compound of claim 1 or 2, wherein n is 1.

5. The compound of any claim 1 to 3, wherein r is 0 or 1.

6. The compound of any claim 1 to 5, wherein A is a bond.

7. The compound of any claim 1 to 5, wherein A is -0-.

8. The compound of any claim 1 to 7, wherein each of X1, X2, X3 and X4 is CRb.

9. The compound of any claim 1 to 8, wherein Rb is hydrogen.

10. The compound of any claim 1 to 9, wherein R1, R2, R3 and R4 are hydrogen.

11. The compound of any claim 1 to 10, wherein R5 is C1-6alkyl.

12. The compound of any claim 1 to 11 , wherein R6 is halo or trifluoromethyl.

13. The compound of any claim 1 to 12, wherein R is Ci_6alkylsulfonyl; Ci_ 6alkylsulfonylamino; aminosulfonyl; or aminocarbonyl.

η

14. The compound of any claim 1 to 13, wherein R is Ci_6alkylsulfonyl.

η

15. The compound of any claim 1 to 13, wherein R is aminosulfonyl.

16. The compound of any claim 1 to 13, wherein R is Ci_6alkylsulfonylamino.

17. The compound of any claim 1 to 13, wherein R is aminocarbonyl.

18. The compound of any claim 1 to 13, wherein R is Ci_6alkylsulfonylamino.

19. The compound of any claim 1 to 18, wherein R is hydrogen.

20. The compound of claim 1 , wherein said compound is of formula III:


wherein:

s is from 0 to2; and

each R9 is independently: Ci-6alkyl; halo; Ci-6alkoxy; or halo-Ci_6alkyl.

21. The compound of claim 1, wherein said compound is of formula IV:

s is from 0 to2; and

each R9 is independently: Ci_6alkyl; halo; Ci_6alkoxy; or halo-Ci_6alkyl.

22. A composition comprising:

(a) a pharmaceutically acceptable carrier; and

(b) a compound of any claim 1 to 21.

23. A method for treating arthritis, said method comprising administering to a subject in need thereof an effective amount of a compound of any claim 1 to 21.

24. A compound according to any one of claims 1 to 21 for use as therapeutically active substance.

25. The use of a compound according to any one of claims 1 to 21 for the treatment or prophylaxis of arthritis.

26. A compound according to any one of claims 1 to 21 for the treatment or prophylaxis of arthritis.

27. The use of a compound according to any one of claims 1 to 21 for the preparation of a medicament for the treatment or prophylaxis of arthritis.

28. The invention as hereinbefore described.