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1. (WO2002085947) SOLUBLE PROTEIN FROM MALARIA PARASITE

Pub. No.:    WO/2002/085947    International Application No.:    PCT/EP2002/004150
Publication Date: Fri Nov 01 00:59:59 CET 2002 International Filing Date: Tue Apr 16 01:59:59 CEST 2002
IPC: A61K 38/17
A61K 39/00
C07K 14/445
Applicants: INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY
CHAUHAN, Virander, Singh
MALHOTRA, Pawan
LALITHA, Punchayil, Velayudhan, Nair
Inventors: CHAUHAN, Virander, Singh
MALHOTRA, Pawan
LALITHA, Punchayil, Velayudhan, Nair
Title: SOLUBLE PROTEIN FROM MALARIA PARASITE
Abstract:
The present invention relates to a method of producing soluble antigenic proteins from a malaria parasite and recovery under non-denaturing conditions, as well as to the production of malaria vaccines thereby. Accordingly, the present invention provides a process of obtaining a non-glycosylated a malaria parasite merozoite surface protein 1 19 kDa C-terminal polypeptide (MSP-119) expressed in soluble form in a prokaryotic host cell without the provision of a fusion partner to assist folding of said MSP-119, said process comprising recovering said MSP-l polypeptide from said cell under non-reducing conditions. It also provides polypeptides produced by such processes and pharmaceutical compositions, especially vaccine compositions, comprising them.