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1. (WO1997035978) PARTIAL INTRON SEQUENCE OF VON HIPPEL-LINDAU (VHL) DISEASE GENE AND ITS USE IN DIAGNOSIS OF DISEASE

Pub. No.:    WO/1997/035978    International Application No.:    PCT/US1997/005059
Publication Date: Fri Oct 03 01:59:59 CEST 1997 International Filing Date: Fri Mar 28 00:59:59 CET 1997
IPC: C07K 14/47
C07K 16/18
C12Q 1/68
Applicants: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Inventors: LINEHAN, Marston, W.
LERMAN, Michael, I.
LATIF, Farida
ZBAR, Berton
Title: PARTIAL INTRON SEQUENCE OF VON HIPPEL-LINDAU (VHL) DISEASE GENE AND ITS USE IN DIAGNOSIS OF DISEASE
Abstract:
The Von Hippel-Lindau (VHL) disease gene and its corresponding cDNA are disclosed. Methods for detecting carriers of the VHL disease gene using probes derived from the VHL disease gene sequence are described. Pharmaceutical compositions and methods of treating diseases related to the VHL gene are also disclosed.