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1. (WO1997020925) MODIFIED VEGF ANTISENSE OLIGONUCLEOTIDES FOR TREATMENT OF SKIN DISORDERS
Dados bibliográficos mais recentes no arquivo da Secretaria Internacional   

№ de pub.:    WO/1997/020925    № do pedido internacional:    PCT/US1996/020441
Data de publicação: 12.06.1997 Data de depósito internacional: 06.12.1996
Pedido de exame (capítulo 2) depositado:    30.06.1997    
CIP:
A61K 38/00 (2006.01), C12N 15/11 (2006.01)
Requerentes: HYBRIDON, INC. [US/US]; 620 Memorial Drive, Cambridge, MA 02139 (US)
Inventores: SMYTH, Adrienne, P.; (US).
ROBINSON, Gregory, S.; (US)
Mandatário: KERNER, Ann-Louise; Hale and Dorr, Sixty State Street, Boston, MA 02109 (US)
Dados da prioridade:
08/569,926 08.12.1995 US
08/629,730 09.04.1996 US
Título (EN) MODIFIED VEGF ANTISENSE OLIGONUCLEOTIDES FOR TREATMENT OF SKIN DISORDERS
(FR) OLIGONUCLEOTIDES ANTISENS SPECIFIQUES DU VEGF, MODIFIES, DESTINES AU TRAITEMENT DES TROUBLES CUTANES
Resumo: front page image
(EN)Disclosed are oligonucleotides complementary to VEGF-specific nucleic acid useful in reducing the expression of VEGF. Also disclosed are pharmaceutical formulations containing such oligonucleotides useful for treating various disorders associated with neovascularization and angiogenesis, and methods for treating psoriasis.
(FR)L'invention concerne des oligonucléotides complémentaires d'un acide nucléique spécifique du facteur de croissance endothélial vasculaire (VEGF), utiles pour diminuer l'expression de ce dernier. Elle concerne également des formulations pharmaceutiques contenant lesdits oligonucléotides, utiles pour le traitement de divers troubles associés à une néovascularisation et à une angiogénèse, ainsi que des méthodes de traitement du psoriasis.
Estados designados: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, UZ, VN.
African Regional Intellectual Property Organization (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Língua de publicação: English (EN)
Língua de depósito: English (EN)