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1. (WO2001014036) PROCESS FOR PRODUCING FINE MEDICINAL SUBSTANCES
Dados bibliográficos mais recentes no arquivo da Secretaria Internacional   

№ de pub.:    WO/2001/014036    № do pedido internacional:    PCT/GB2000/003178
Data de publicação: 01.03.2001 Data de depósito internacional: 18.08.2000
Pedido de exame (capítulo 2) depositado:    15.02.2001    
CIP:
A61K 9/16 (2006.01), B01D 9/00 (2006.01), B01F 3/08 (2006.01), B01F 5/00 (2006.01), B01F 5/02 (2006.01), B01F 13/00 (2006.01)
Requerentes: AVENTIS PHARMA LIMITED [GB/GB]; Aventis House, 50 Kings Hill Avenue, West Malling, Kent ME19 4AH (GB) (For All Designated States Except US).
BEGON, Dominique [FR/FR]; (FR) (For US Only).
GUILLAUME, Pfefer [FR/FR]; (FR) (For US Only).
KOHL, Michael [FR/FR]; (FR) (For US Only)
Inventores: BEGON, Dominique; (FR).
GUILLAUME, Pfefer; (FR).
KOHL, Michael; (FR)
Mandatário: JONES, Stephen, Anthony; AdamsonJones, Broadway business Centre, 32a Stoney Street, Nottingham, NG1 1LL (GB)
Dados da prioridade:
9919693.3 19.08.1999 GB
Título (EN) PROCESS FOR PRODUCING FINE MEDICINAL SUBSTANCES
(FR) PROCEDE DE PRODUCTION DE SUBSTANCES MEDICINALES FINES
Resumo: front page image
(EN)The method of producing fine medicament particles suitable for inhalation, particles produced by the method and apparatus suitable for carrying out the method is claimed. The method comprises contacting a stream or streams of a solution of medicament with a stream or streams of a liquid in which the medicament is insoluble in a confined chamber such that a region of intense turbulence and mixing is formed. The medicament crystallises as fine particles with minimal inclusion of solvent or anti-solvent impurities. The crystallised medicament is separated from suspension by standard techniques. Careful control of relative stream velocity, solution concentration and proportion of solution and anti-solvent in the streams ensures a uniform product.
(FR)L'invention concerne un procédé de production de fines particules médicinales pouvant être inhalées, des particules produites selon ce procédé et un dispositif permettant de le mettre en oeuvre. Ce procédé consiste à mettre en contact, dans une enceinte confinée, au moins un flux d'une solution de médicament avec au moins un flux d'un liquide dans lequel le médicament n'est pas soluble, de manière à former une région de forte turbulence et de mélange. Le médicament cristallise sous forme de fines particules, avec l'inclusion minimale d'impuretés de solvant ou d'anti-solvant. On sépare ensuite le médicament cristallisé de la suspension par des techniques classiques. Une régulation minutieuse de la vitesse relative des flux, de la concentration de la solution ainsi que de la proportion de solution et d'anti-solvant dans les flux assure un produit uniforme.
Estados designados: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Língua de publicação: English (EN)
Língua de depósito: English (EN)