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1. (WO2007149211) DIHYDROOROTATE DEHYDROGENASE INHIBITORS WITH SELECTIVE ANTI-MALARIAL ACTIVITY
Dados bibliográficos mais recentes no arquivo da Secretaria Internacional   

№ de pub.:    WO/2007/149211    № do pedido internacional:    PCT/US2007/013161
Data de publicação: 27.12.2007 Data de depósito internacional: 05.06.2007
CIP:
A61K 31/47 (2006.01), C07D 215/02 (2006.01)
Requerentes: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM [US/US]; 201 West 7th Street, Austin, TX 78701 (US) (For All Designated States Except US).
PHILLIPS, Margaret [US/US]; (US) (For US Only).
RATHOD, Pradipsinh, K. [US/US]; (US) (For US Only).
BALDWIN, Jeffery [US/US]; (US) (For US Only).
GUJJAR, Ramesh [IN/US]; (US) (For US Only)
Inventores: PHILLIPS, Margaret; (US).
RATHOD, Pradipsinh, K.; (US).
BALDWIN, Jeffery; (US).
GUJJAR, Ramesh; (US)
Mandatário: BENT, Stephen, A.; Foley & Lardner LLP, Wahshington Harbour, 3000 K Street NW, Suite 500, Washington, DC 20007-5143 (US)
Dados da prioridade:
60/815,568 22.06.2006 US
Título (EN) DIHYDROOROTATE DEHYDROGENASE INHIBITORS WITH SELECTIVE ANTI-MALARIAL ACTIVITY
(FR) INHIBITEURS DE LA DIHYDROOROTATE DÉSHYDROGÉNASE AVEC ACTIVITÉ ANTI-MALARIQUE SÉLECTIVE
Resumo: front page image
(EN)Pharmaceutical compositions comprising compounds of the formula (I) where R1, R2, and R3 are described here, have therapeutic utility in selectively inhibiting P. falciparum dihydroorotate dehydrogenase. Accordingly, such compositions have use in the treatment and prevention of malaria.
(FR)L'invention concerne des compositions pharmaceutiques comprenant des composés de la formule (I), dans laquelle R1, R2, et R3 sont décrits ici, ayant une utilité thérapeutique pour inhiber sélectivement la dihydroorotate déshydrogénase de P. falciparum. En conséquence, de telles compositions ont une utilisation dans le traitement et la prévention de la malaria.
Estados designados: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Língua de publicação: English (EN)
Língua de depósito: English (EN)