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1. (WO2014121077) METHOD FOR GENERATING RETINAL PIGMENT EPITHELIUM (RPE) CELLS FROM INDUCED PLURIPOTENT STEM CELLS (IPSCs)
Dados bibliográficos mais recentes no arquivo da Secretaria Internacional   

№ de pub.:    WO/2014/121077    № do pedido internacional:    PCT/US2014/014160
Data de publicação: 07.08.2014 Data de depósito internacional: 31.01.2014
CIP:
C12N 5/079 (2010.01), C12N 5/074 (2010.01)
Requerentes: THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; National Institutes of Health Office of Technology Transfer 6011 Executive Boulevard Suite 325, MSC 7660 Bethesda, MD 20852-7660 (US)
Inventores: BHARTI, Kapil; (US).
DAVIS, Janine; (US).
MAMINISHKIS, Arvydas; (US).
FERRER-ALEGRE, Marc; (US).
MILLER, Sheldon, S.; (US)
Mandatário: SIEGEL, Susan, Alpert; Klarquist Sparkman, LLP One World Trade Center, Suite 1600 121 SW Salmon Street Portland, OR 97204 (US)
Dados da prioridade:
61/759,988 01.02.2013 US
Título (EN) METHOD FOR GENERATING RETINAL PIGMENT EPITHELIUM (RPE) CELLS FROM INDUCED PLURIPOTENT STEM CELLS (IPSCs)
(FR) PROCÉDÉ DE GÉNÉRATION DE CELLULES ÉPITHÉLIALES PIGMENTAIRES RÉTINIENNES (EPR) À PARTIR DE CELLULES SOUCHES PLURIPOTENTES INDUITES (CSPI)
Resumo: front page image
(EN)High efficiency methods for producing retinal pigment epithelial cells from induced pluripotent stem cells (iPSCs) are disclosed herein. The iPSCs are produced from somatic cells, including retinal pigment epithelial (RPE) cells, such as fetal RPE stem cells. In some embodiments, the iPSC include a tyrosinase promoter operably linked to a marker. Methods are disclosed for using the RPE cells, such as for treatment. Methods for screening for agents that affect RPE differentiation are also disclosed.
(FR)La présente invention concerne des procédés très efficaces de production de cellules épithéliales pigmentaires rétiniennes à partir de cellules souches pluripotentes induites (CSPi). Les CSPi sont produites à partir de cellules somatiques et, notamment, de cellules épithéliales pigmentaires rétiniennes (EPR), telles que les cellules souches EPR fœtales. Selon certains modes de réalisation, les CSPi comprennent un promoteur de la tyrosinase en liaison fonctionnelle avec un marqueur. L'invention concerne également des procédés d'utilisation desdites cellules EPR, par exemple à des fins de traitement. L'invention concerne, en outre, des procédés de criblage permettant de rechercher des agents ayant une incidence sur la différentiation des cellules EPR.
Estados designados: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Língua de publicação: English (EN)
Língua de depósito: English (EN)